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Brain Storms
- The Race to Unlock the Mysteries of Parkinson's Disease
- Narrated by: Sean Runnette
- Length: 7 hrs and 52 mins
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Publisher's Summary
Seven million people worldwide suffer from Parkinson's, and doctors, researchers, and patients continue to hunt for a cure. In Brain Storms, the award-winning journalist Jon Palfreman tells their story, a story that became his own when he was diagnosed with the debilitating illness. Palfreman chronicles how scientists have worked to crack the mystery of what was once called the shaking palsy, from the earliest clinical descriptions of tremors, gait freezing, and micrographia to the cutting edge of neuroscience, and charts the victories and setbacks of a massive international effort to best the disease. He takes us back to the late 1950s and the discovery of L-dopa. He delves into a number of other therapeutic approaches to this perplexing condition, from partial lobotomies and deep brain stimulation to neural grafting. And he shares inspiring stories of brave individuals living with Parkinson's, from a former professional ballet dancer who tricks her body to move freely again to a patient who cannot walk but astounds doctors when he is able to ride a bicycle with no trouble at all.
With the baby boom generation beginning to retire and the population steadily aging, the race is on to discover a means to stop or reverse neurodegenerative conditions like Parkinson's and Alzheimer's. Brain Storms is the long-overdue, riveting, and deeply personal story of that race and a passionate, insightful, and urgent look into the lives of those affected.
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What listeners say about Brain Storms
Average Customer RatingsReviews - Please select the tabs below to change the source of reviews.
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- Neuron
- 09-27-15
Explains the science and its significance
Too many popular science books fall into one of two categories. On the one hand you have books that describe the science accurately, mentioning all sources of uncertainty, but then fails to convey the implications in an interesting manner. Then there are books that use the science like a drunken man uses a light post - for support rather than illumination. Such books can give you a gripping story and then a few references are thrown in to make the story seem credible, but they fail to explain the science behind the story.
This book finds the perfect sweet-spot in that it describes the in an intriguing but fair manner while also continually reminding the reader what the science means for the reader - whether that is someone afflicted with Parkinson or someone who is just interested in the disease. The story is told in a chronological manner, beginning with James Parkinson who first described the syndrome/disease that now bears his name. In the 1960s, more than a century after, came the first effective treatments for the disease. Levadopa (L-Dopa), a dopamine pre-cursor, showed promising results at first. What I didn’t know is that in the first blind study there was no difference between patients receiving Levadopa, and the group receiving a placebo. It was only after some tinkering with the doses that Levadopa became the main drug for alleviating symptoms that it is today.
Palfreman’s who himself has Parkinson writes about all the different approaches to curing or alleviating Parkinson, including, L-dopa, neural grafting, deep brain stimulation, growth factors, and viral destruction of misfolded proteins. The stories for these treatments can appear, and often are rather repetitive. It begins with galumphing scientists and foundations who believe they have found a potential cure for Parkinson and that they can make the disease vanish if they are given sufficient funds. Initial “open label” studies often show positive results, but then a blind study reveals that there is no difference between the treatment and a placebo. This seems to be the pattern for all treatments except for Levadopa and deep brain stimulation. Yet it is important to remember that the first Levadopa trial also showed negative results. New trials with new treatments are underway and personally I think that it is a matter of time before we find new treatments for the disease.
One type of “treatment” which is also appear to be effective and which is not invasive is exercise. Regular exercise can have a large effect on all symptoms related to the disease. Like with many other types of diseases that afflicts the elderly, it seems crucial to maintain an active lifestyle, both socially and in terms of physical exercise, if you want to slow the disease. Another aspect that Palfreman writes about is the placebo effect, which in the case of Parkinson is very large. One study found that Parkinson patients receiving a sham surgery often showed marked improvements in their symptoms which could last years. It is a shame you cannot manufacture the placebo effect, but the results clearly show that the mindset of the patient with Parkinson can have a surprisingly large effect on the way the disease is perceived.
Although I do not have Parkinson and the disease has not been a focal interest in my PhD studies, I was still captivated by Palfreman’s story, and the book really is an excellent book for anyone who want to understand how science progresses. It is a road that is more bumpy than most people tend to think. I think the book is also perfect for someone who has Parkinson because, despite all the setbacks in the field there is still hope. The book does not say that there will be a cure within five or even ten years (which would be unethical to say), but you can still sense the hope that someday (perhaps sooner rather than later), a new effective treatment will come.
25 people found this helpful
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- Laura
- 10-01-15
Great Journalistic Work
Any additional comments?
From the get-go, I knew Brain Storms was going to be a fascinating story. Part investigation and part memoir, journalist Jon Palfreman incorporates medical research and interviews with patients and doctors into a captivating biography of Parkinson’s. Recently diagnosed with the disease, Palfreman brings a personal and emotional element rarely witnessed in a book such as this. Brain Storms not only highlights the medical strides made in the field of neurodegenerative disorders, but also charts the vast setbacks researchers used to, and still do face. With so few books tackling Parkinson’s, this book is a much needed addition to any nonfiction fan’s library.
8 people found this helpful
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- Ryan
- 09-17-15
Riveting tale of the quest to cure a difficult disease
Wow, this audiobook was so interesting I got through it in just 1 day. I couldn't stop listening.
This book goes through the history of Parkinson's disease, explains the disease and every major attempt at curing or slowing it's progress...as well as the many unfortunate setbacks.
A great book that I learned a lot from and would recommend to anyone interested in this disease or neuroscience in general.
7 people found this helpful
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- EmeraldIsle
- 05-25-16
Great informative listen
Truly appreciated the author's perspective. Listened more than once because of all the helpful information
3 people found this helpful
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- Giorgio Bonmassar
- 12-09-15
Great book on Parkinson ' s disease
A great way to learn the latest, past and present attempts to treat PD, extremely well written by a BBC journalist that contracted the disease.
3 people found this helpful
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- David Murray
- 03-10-16
Excellent-A Courageous Gift
As someone whose best friend, an accomplished physician (recently retired), was just diagnosed with Parkinson's, this book met all my needs in understanding the disease, its history, the development of both failed & successful drugs & treatments and, most importantly, the status of some recent discoveries, as of 2015.
Hopefully, the trials of antibody-like 'drugs' such as NeuroPhage's NPT088 will be successful.
The book is written in a clear and well laid out manner considering such a complex subject. It will appeal to both the layman and professional. The narrator, Sean Runnette, as usual, is excellent.
2 people found this helpful
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- Daniel Crumbo
- 10-28-15
An excellent take on a difficult subject
A thoughtful, insightful, strikingly well-written, and soberly optimistic view into the history and future of the science of Parkinson's. An even better account of the people who battle with, survive, and succumb to the disease. Beyond its proximate subject, Palfreman's book is a exploration of coping and perseverance, and a nuanced take on faith, science, and faith in science.
2 people found this helpful
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- Penny
- 10-21-15
Excellent update
What made the experience of listening to Brain Storms the most enjoyable?
An extremely valuable book for both the layperson and the medical professional. I am recommending it to friends and have purchased copies for caregivers of my mother. As a pharmacist I learned much more than I knew. I will be advising my many medical friends to read it as well. Excellent explanation of the affliction and the newest advances regarding its treatment.
2 people found this helpful
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- maya
- 07-22-21
Very intersting
It was my first book on the subject, and it was insightful in an interesting way.
1 person found this helpful
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- Maggee B
- 12-25-20
Amazing Book !
this book better explains PD and the history of study & treatment than any other
1 person found this helpful
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Dr. Okun is well-known for infusing his audiences with positivity and optimism. In this book, he reveals the breakthroughs and therapies surrounding Parkinson's disease that will pave the road to meaningful progress, which extends far beyond a single drug or stem cell. He paints the broader and more exciting picture and reviews the portfolio of breakthroughs spanning drug, cell, vaccine, device, genetics, care, and behavior.
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What breakthroughs?
- By Matthew on 10-27-18
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Parkinson's Disease
- A Complete Guide for Patients and Families, Third Edition
- By: William J. Weiner MD, Lisa M. Shulman MD, Anthony E. Lang MD FRCP
- Narrated by: Bob Souer
- Length: 10 hrs and 24 mins
- Unabridged
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Recent innovations, including deep brain stimulation and new medications, have significantly improved the lives of people who have Parkinson's disease. Nevertheless, patients and families continue to face many challenges. They have long relied on this book for reliable advice about medical, emotional, and physical issues. Bringing this trusted guide up to date, three expert neurologists describe new understandings gained by five years of additional research on Parkinson's disease.
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Spectacular book!
- By Amanda Hodges on 07-15-21
By: William J. Weiner MD, and others
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Parkinson's Treatment: 10 Secrets to a Happier Life: English Edition
- By: Michael S Okun MD
- Narrated by: Rich Germaine
- Length: 3 hrs and 46 mins
- Unabridged
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Parkinson's Treatment English Edition: 10 Secrets to a Happier Life is available in over 20 language translations, so that all worldwide cultures can have access to the secrets that can help those living with Parkinson's disease. Additionally the book addresses all of the new and emerging Parkinson's disease therapies (stem cells, gene therapy, optogenetics, etc.). The most humbling experience of my life has been the time I have spent with families, and with patients suffering from Parkinson's and chronic neurological diseases.
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Dr. Okun misses the point
- By John on 09-23-14
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Parkinson's Regeneration Training: Neuropsychomotor Rehabilitation
- An Integrated and Fitness-Based Approach to Improving Movement and Cognition
- By: Karl Sterling, Perry Nickelston, Nicholas Sterling, and others
- Narrated by: Scott Hoke
- Length: 11 hrs and 43 mins
- Unabridged
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While Parkinson’s Disease can be debilitating, there is plenty of compelling data to show that exercise is one of the best ways of managing PD symptoms. Studies show that regular exercise can improve gait, grip, balance, stability, strength, and motor control in the PD client. In addition, this improvement in movement and mobility helps to reduce falls, injuries, and various other complications of the disease in the PD client.
By: Karl Sterling, and others
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The Complete Guide for People with Parkinson's Disease and Their Loved Ones
- By: Lianna Marie
- Narrated by: Coleen Marlo
- Length: 5 hrs and 10 mins
- Unabridged
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A diagnosis of Parkinson's disease is as disorienting as it is devastating. The Complete Guide for People with Parkinson's Disease and Their Loved Ones helps make sense of what comes next and what can be done, not just for those suffering from the disease, but for their family and friends as well.
By: Lianna Marie
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Parkinson's Disease for Dummies
- By: Michele Tagliati MD, Gary N. Guten MD MA, Jo Horne MA, and others
- Narrated by: Wendy Tremont King
- Length: 15 hrs and 52 mins
- Unabridged
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If you or someone you love has been diagnosed with Parkinson's Disease, you're probably wrestling with fear, despair, and countless questions about the future. It's brighter than you think. In Parkinson's Disease for Dummies, you'll discover how to keep a positive attitude and lead an active, productive life as this user-friendly, guide pilots you through the important steps toward taking charge of your condition.
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NjmS
- By Nancy on 08-15-19
By: Michele Tagliati MD, and others
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10 Breakthrough Therapies for Parkinson's Disease
- By: Michael S. Okun MD
- Narrated by: Rich Germaine
- Length: 4 hrs and 51 mins
- Unabridged
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Dr. Okun is well-known for infusing his audiences with positivity and optimism. In this book, he reveals the breakthroughs and therapies surrounding Parkinson's disease that will pave the road to meaningful progress, which extends far beyond a single drug or stem cell. He paints the broader and more exciting picture and reviews the portfolio of breakthroughs spanning drug, cell, vaccine, device, genetics, care, and behavior.
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What breakthroughs?
- By Matthew on 10-27-18
Related to this topic
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In Pursuit of Memory
- The Fight Against Alzheimer's
- By: Joseph Jebelli
- Narrated by: Thomas Judd
- Length: 7 hrs and 45 mins
- Unabridged
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For readers and listeners of Atul Gawande, Siddhartha Mukherjee, and Henry Marsh, a riveting, gorgeously written biography of one of history's most fascinating and confounding diseases - Alzheimer's - from its discovery more than 100 years ago to today's race toward a cure.
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Hopeless and dry
- By Shauna on 04-24-19
By: Joseph Jebelli
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The Inflamed Mind
- A Radical New Approach to Depression
- By: Edward Bullmore
- Narrated by: Sean Patrick Hopkins, Edward Bullmore - foreword
- Length: 6 hrs and 25 mins
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In this game-changing audiobook, University of Cambridge profressor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how, and why, we now know that mental disorders can have their root cause in the immune system and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression.
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I can relate as a suffer
- By Robert S. on 01-25-19
By: Edward Bullmore
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The Philadelphia Chromosome
- A Mutant Gene and the Quest to Cure Cancer at the Genetic Level
- By: Jessica Wapner
- Narrated by: Heather Henderson
- Length: 9 hrs and 43 mins
- Unabridged
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Almost daily, headlines announce newly discovered links between cancers and their genetic causes. Science journalist Jessica Wapner vividly relates the backstory behind those headlines, reconstructing the crucial breakthroughs, explaining the science behind them, and giving due to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 50,000 people diagnosed each year with chronic myeloid leukemia (CML).
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Great topic for those in medicine
- By Ronda on 03-17-16
By: Jessica Wapner
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Cells Are the New Cure
- The Cutting-Edge Medical Breakthroughs That Are Transforming Our Health
- By: Sanjay Gupta MD - Foreword, Max Gomez PhD, Robin L. Smith MD
- Narrated by: Randye Kaye
- Length: 8 hrs and 35 mins
- Unabridged
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Promising treatments now in more than 35,000 clinical trials could have dramatic impacts on cancer, autoimmune diseases, organ replacement, heart disease, and even aging itself. These treatments, which are saving the lives of patients in the trials, will soon be rolled to the medical community at large. The key to these breakthroughs is the use of living cells as medicine instead of traditional drugs. Research has found that our bodies are virtual treasure troves of adult cells that act as agents of remarkable healing and repair.
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Amazing! Must listen!
- By Max pavlovich on 04-30-18
By: Sanjay Gupta MD - Foreword, and others
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Tripping Over the Truth
- The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure
- By: Travis Christofferson
- Narrated by: Clay Lomakayu
- Length: 9 hrs and 38 mins
- Unabridged
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A masterful synchronization of history and cutting-edge science shines new light on humanity's darkest diagnosis. In the wake of the Cancer Genome Atlas project's failure to provide a legible road map to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease.
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Non-fiction books - please include references
- By yaelb on 06-15-16
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The Beautiful Cure
- The Revolution in Immunology and What It Means for Your Health
- By: Daniel M. Davis
- Narrated by: Jot Davies
- Length: 8 hrs and 24 mins
- Unabridged
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The immune system holds the key to human health. In The Beautiful Cure, leading immunologist Daniel M. Davis describes how the scientific quest to understand how the immune system works - and how it is affected by stress, sleep, age, and our state of mind - is now unlocking a revolutionary new approach to medicine and well-being. The body's ability to fight disease and heal itself is one of the great mysteries and marvels of nature. But in recent years, painstaking research has resulted in major advances in our grasp of this breathtakingly beautiful inner world....
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Wonderful Book about your Immune System
- By Brad Armstrong on 06-05-19
By: Daniel M. Davis
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In Pursuit of Memory
- The Fight Against Alzheimer's
- By: Joseph Jebelli
- Narrated by: Thomas Judd
- Length: 7 hrs and 45 mins
- Unabridged
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Overall
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Performance
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Story
For readers and listeners of Atul Gawande, Siddhartha Mukherjee, and Henry Marsh, a riveting, gorgeously written biography of one of history's most fascinating and confounding diseases - Alzheimer's - from its discovery more than 100 years ago to today's race toward a cure.
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Hopeless and dry
- By Shauna on 04-24-19
By: Joseph Jebelli