Uterine aging plays a critical hidden role in IVF outcomes

Fertility specialist Oluyemisi Famuyiwa discusses her article "Uterine aging in IVF: Why the 'soil' matters as much as the seed." Oluyemisi explains that while clinicians often focus on egg quality, the aging of the uterus itself is a frequently overlooked factor in implantation failure. She explores clinical data showing that even with chromosomally perfect embryos, success rates decline as the endometrium loses its resilience due to cellular senescence and weakened progesterone signaling. The conversation challenges the standard "seed and soil" analogy by revealing that normal ultrasound thickness does not guarantee a receptive environment for pregnancy. Oluyemisi advocates for a precision medicine approach that scrutinizes the uterine environment as rigorously as the embryo to refine hope for patients. Discover how acknowledging the biological history of the uterus can transform unexplained failure into actionable data.

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