GLP-1s, TRT, and Training: What Lifters & Coaches Need to Know

GLP-1 medications, TRT, and peptides are becoming common—but they don't change the rules of strength training. Learn how GLP-1s and strength training work together to preserve muscle, manage recovery, and train intelligently for long-term health.

In this episode of Beast Over Burden, hosts Niki Sims and Andrew Jackson unpack how GLP-1 medications, TRT, and peptides are changing the coaching landscape—and what that means for strength training.

Drawing from years of hands-on coaching experience, Andrew explains how GLP-1s and strength training interact, why muscle preservation becomes critical during rapid fat loss, and how tools like TRT can accelerate progress without changing the core rules of adaptation.

If you're a lifter training on GLP-1 medications, considering TRT, or a coach working with clients using these tools, this episode delivers a first-principles framework for protecting muscle, managing recovery, and training for long-term health.

What You'll Learn in This Episode

• How GLP-1s and strength training interact in real lifters

• Why training on GLP-1 medications increases the need for muscle preservation

• Common fatigue, nutrition, and recovery challenges with GLP-1s

• How TRT affects recovery, training frequency, and progress

• Why first principles still apply—even with hormone support

• How coaches should think about programming for clients on GLP-1s or TRT

• The role of protein, resistance training, and bone density during rapid fat loss

• Why communication between lifter and coach matters more than ever

• How peptides fit into recovery—and where their limits are

• Why long-term quality of life should guide training decisions

Timestamps

00:00 – Intro: Niki & Andrew set the stage
02:10 – The biggest shift Andrew has seen in 10 years of coaching
04:30 – What counts as hormone-influencing tools (GLP-1s, TRT, peptides)
07:20 – Why GLP-1 medications reduce appetite—and what that changes
10:45 – Training on GLP-1s: fatigue, low energy, and muscle loss risk
14:30 – Fat loss vs muscle preservation: why strength training matters
18:05 – TRT and strength training: the return of linear progress
22:40 – Recovery, frequency, and why TRT doesn't remove limits
26:15 – Peptides, recovery, and optimization myths
30:10 – Coaching clients on GLP-1s: why honesty matters
34:25 – Nutrition priorities when appetite is suppressed
38:10 – Bone density, muscle mass, and aging well
42:00 – First principles that never change
46:00 – Final thoughts: tools don't replace training
48:10 – How to work with a Barbell Logic coach

Key Takeaway

GLP-1s, TRT, and peptides may change the training landscape—but they don't change the map. Strength training, protein intake, recovery, and intelligent coaching still determine long-term results.

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Start your transformation: https://bit.ly/4rKpkLr Connect with the hosts

• Niki on Instagram
• Andrew on Instagram

Connect with the show

• Barbell Logic on Instagram
• Podcast Webpage
• Barbell Logic on Facebook
• Or email [e-mail]