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Amos 'n' Andy is an American radio sitcom about black characters, initially set in Chicago and later in the Harlem section of New York City. While the show had a brief life on 1950s television with black actors, the 1928 to 1960 radio show was created, written and voiced by two white actors, Freeman Gosden and Charles Correll, who played Amos Jones (Gosden) and Andrew Hogg Brown (Correll), as well as incidental characters. On television, 1951–1953, black actors took over the majority of the roles; white characters were infrequent.

Amos 'n' Andy began as one of the first radio comedy series and originated from station WMAQ in Chicago. After the first broadcast in 1928, the show became a hugely popular series, first on NBC Radio and later on CBS Radio and Television. Early episodes were broadcast from the El Mirador Hotel in Palm Springs, California.: 168–71  The show ran as a nightly radio serial (1928–43), as a weekly situation comedy (1943–55) and as a nightly disc-jockey program (1954–60). A television adaptation ran on CBS (1951–53) and continued in syndicated reruns (1954–66). It was not shown to a nationwide audience again until 2012.