Your Friday Five: Restarting GLP-1s Postpartum—What to Expect

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This week’s Friday Five tackles a question many women quietly wonder about:
“What should I expect if I restart Mounjaro after pregnancy and breastfeeding?”

Whether you paused your GLP-1 for pregnancy, breastfeeding, or simply life circumstances, coming back to it after many months brings up a lot of unknowns. In this episode, I break down what typically happens, what we actually know from emerging research, and most importantly—why postpartum women need close, compassionate medical support.

Inside the episode, we explore:

1. What current guidelines say about GLP-1s, pregnancy, and breastfeeding

The traditional recommendation is stopping GLP-1s two months before trying to conceive and waiting until you’re done breastfeeding to restart.
But I also share a recent small study looking at semaglutide and its transfer into breast milk—and what that means (and doesn’t mean) for real-life decisions.

2. Why restarting after long-term use often looks different

If you were previously on Mounjaro for 6–24 months, your body typically:

• tolerates the medication more easily
• can often titrate up more quickly
• experiences fewer early side effects
  Some of this is physiologic, some behavioral—because you’ve already learned hydration, fiber strategies, and the day-after-injection do’s and don’ts.

3. The postpartum period is the “fourth trimester”—and it changes everything

Exhaustion, unpredictable schedules, stress, hormones, sleep deprivation… postpartum is not just a season. It’s a vulnerable season.
This is why you should never “go cowboy alone” when restarting medication.
A skilled clinician helps prevent:

• excessive restriction
• metabolic overwhelm
• worsening mood
• tipping into depression or anxiety
• extreme titration that backfires

4. How ongoing support during pregnancy impacts your restart

I share examples from my own clinic:
Some women stay with me through pregnancy—not for weight loss, but for structure, nutrition support, and a stable relationship with food.
Those women often find it much easier to restart postpartum because they never disconnected from caring for their bodies.

5. The good news: most women feel relief when they restart

Once medically cleared and supported, many women say:

• their appetite becomes manageable again
• their mental load decreases
• their urges and cravings quiet down
• they finally feel like they have help

And that’s the whole point: to feel supported, not stressed.

If you’re in this season, I’m rooting for both your health and your baby’s health. Postpartum is not a time to go it alone, and you deserve expert guidance every step of the way.

I hope this episode gives you clarity, comfort,

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

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