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https://greymattershealth.org/

https://www.apollohealthco.com/

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Summary

Dr. Dale Bredesen, a neuroscientist and neurologist, discusses the failures of traditional approaches to Alzheimer's disease and presents his groundbreaking protocol for reversing cognitive decline. He emphasizes the need to understand the underlying mechanisms of the disease and address the network insufficiency that leads to cognitive decline. Dr. Bredesen shares stories of patients who have experienced significant improvements on his protocol and highlights the importance of personalized treatment. He also challenges the current focus on amyloid plaque as the primary cause of Alzheimer's and suggests that it may be a natural protective mechanism rather than a pathological factor. Dr. Dale Bredesen discusses the different subtypes of Alzheimer's disease and the corresponding treatment protocols. He explains that Alzheimer's is a network insufficiency disease and that there are multiple contributors to the disease, including inflammation, hormonal imbalances, toxins, and vascular issues. The treatment approach involves identifying and addressing the specific contributors for each individual. Dr. Bredesen emphasizes the importance of early detection and intervention, as well as the need for a personalized and comprehensive approach to treatment. He also discusses the role of telemedicine and the availability of his protocols through Grey Matters and Apollo Health.

Takeaways

Traditional approaches to Alzheimer's disease have been unsuccessful in reversing cognitive decline.

Dr. Bredesen's protocol focuses on addressing the network insufficiency that leads to cognitive decline.

Personalized treatment is key, as the underlying mechanisms and contributing factors can vary from person to person.

Amyloid plaque may be a natural protective mechanism rather than the primary cause of Alzheimer's disease. Alzheimer's disease is a network insufficiency disease with multiple contributors.

Treatment protocols should be personalized and address the specific contributors for each individual.

Early detection and intervention are crucial for better outcomes.

Telemedicine offers opportunities for remote access to treatment and monitoring.

Grey Matters and Apollo Health provide resources and training for practitioners and patients.

Chapters

00:00 Introduction to Dr. Dale Bredesen

01:27 The Failure of Traditional Approaches to Alzheimer's

04:49 Understanding the Underlying Mechanisms

08:14 The Importance of Personalized Treatment

13:23 Rethinking the Role of Amyloid Plaque

21:27 Patient Stories and Examples

32:51 The Need for More Data and Compassionate Use

48:36 Understanding Alzheimer's as a Network Insufficiency Disease

54:55 Targeting Inflammation and Using Resolvins for Treatment

57:49 Addressing Reduced Appetite and Absorption in the Atrophic Subtype

58:48 Detoxification for the Toxic Subtype of Alzheimer's

01:02:34 The Role of Hormones in Brain Function and Treatment

01:11:40 Treatment Possibilities for Late-Stage Alzheimer's

01:14:04 The Benefits of Omega-3s for Cognitive Decline

01:15:44 Accessing Treatment through Grey Matters and Apollo Health

01:19:30 The Potential of Telemedicine in Alzheimer's Treatment

01:23:39 The Future of Alzheimer's Treatment and Brain Aging

Dr. Bill Harris, a leading researcher in the omega-3 fatty acid field, discusses the basics of fatty acids and the importance of omega-3s. He explains that omega-3s are a subset of polyunsaturated fatty acids and are metabolically active, playing a role in building cell membranes and regulating inflammatory responses. He also addresses the misconception that omega-6 fatty acids are bad, emphasizing that they are essential and have their own functions. Dr. Harris discusses the potential risks of high-dose omega-3 supplementation, including a small increased risk of atrial fibrillation. He recommends a daily intake of about 1 gram of EPA and DHA for optimal health. He also highlights the benefits of omega-3 supplementation for pregnant women and athletes. Omega-3 fatty acids have been extensively studied and have shown numerous health benefits. They have been found to reduce the risk of heart disease, improve brain health, support the immune system, and potentially reduce the risk of certain autoimmune diseases. The Omega-3 Index, a blood test that measures the levels of EPA and DHA in red blood cells, is a valuable tool for assessing omega-3 status and predicting health outcomes. The form of omega-3 supplementation, whether triglyceride, ethyl ester, or phospholipid, does not seem to significantly impact its effectiveness. The future of omega-3 supplementation may involve alternative sources such as microalgae or genetically modified plants.

One of Dr. Harris' legacy yearnings is to raise the collective omega-3 levels of his fellow human beings around the world. If you are engaged in any activity that could partner with that mission, he would welcome your inquiry at the following contact points:

You can follow the work of Dr. Bill Harris on the Fatty Acid Research Institute website: https://www.faresinst.org/

Email: wsh@faresinst.com

Email: info@omegaquant.com

Youtube: @omegaquantlab

Instagram: @omegaquant

LinkedIn: Omegaquant Analytics

His Omega-3 Index blood spot test that you can do at home is available on https://omegaquant.com/. To help promote their importance, while supplies last I have set the Omega-3 Index Basic Test as a non-profit item in my store https://store.hormonespecialist.net/.

Enjoy his Omega Matters podcast at: https://omegaquant.com/omegamatters-broadcasts/

What’s in the pipeline? Lots of stuff!

• A paper looking at the effects of fish oil supplements on RBC and WBC fluidity and flexibility… somewhat surprising finding – Om3 seem to influence the membrane physiochemical properties of the latter more than the former.
• UK Biobank paper on the association between Linoleic acid levels and risk for total and cause-specific mortality. More evidence of the healthfulness of LA!
• Another UKBB project on omega-3 levels and risk for heart failure (good, as expected)
• An updated world map of omega-3 index status by country – things look a little better than they did in 2016 when the first map was produced, but still way too low almost everywhere

00:00 Introduction of Dr. Bill Harris 03:23 Understanding Fatty Acids and the Importance of Omega-3s 11:50 Dispelling the Myth of Omega-6 Fatty Acids 41:04 Recommended Daily Intake of Omega-3s for Optimal Health 49:46 The Benefits of Omega-3 Supplementation for Pregnant Women and Athletes 51:42 The Health Benefits of Omega-3 Fatty Acids 01:07:29 The Importance of the Omega-3 Index 01:13:12 The Impact of Omega-3 on Health Outcomes 01:19:07 Different Forms of Omega-3 Supplementation 01:29:47 The Future of Omega-3 Supplementation

My guest and your advisor today is medical anthropologist and investigative journalist, Scott Carney. It doesn't take a long conversation with him to see that he loves both. And the NYT Best Seller status of his book "What Doesn't Kill Us," proves he's good at it. The book is a first hand examination of the methods of one Wim Hof, a Dutch guru of extreme cold exposures and accessing powers of adaption that lie within all of us but have gone largely dormant with the modern-day comforts we clever humans have secured for ourselves. But the technique is not without risk. Scott has just revealed for the first time some newly emerging evidence that the practice can go tragically wrong. What I like about Scott is he breaks down this concept of hormesis in human physiology with the clarity of a skilled journalist and the spell of a good storyteller. Things we could use a lot more of in science education. I think you'll find his humor and energy are infectious. Scott is definitely more the Indiana Jones anthropologist rather than the academic. He's going to love me for that! Never one to study his subject by passive observation, his style is complete immersion and full participation , which makes for really interesting material. So let's get to it! Find Scott on Youtube @sgcarney Timestamps: 00:00:00-00:01:37 Scott Carney Intro 00:01:38-00:02:56 Scott’s Background in Medical Anthropology 00:02:57-00:06:10 Intro to What Does’t Kill Us 00:06:11-00:10:31 What is hormesis? 00:10:32-00:13:18 The Wim Hof Method 00:13:19-00:16:34 Scott begins investigating Wim How 00:16:35-00:18:39 Adapting for survival 00:18:40-00:25:29 Our quest for comfort makes us uncomfortable everywhere 00:25:30-00:30:17 Turning off immune system using Wim Hof method 00:30:18-00:34:56 Placing a wedge between stimulus and response 00:34:57-00:36:04 The wedge and pain, anxiety, depression, auto immune disease 00:36:05-00:42:01 Wim, his twin, and brown fat 00:42:02-00:43:39 The theory of reductionism 00:43:40-00:53:54 Scott hikes Mt Kilimanjaro in -30 degree temperatures shirtless, using Wim Hof breathing technique 00:53:55-00:56:20 I’m not on the mountain, I am the mountain mindset 00:56:21-01:00:54 A mutiny on the mountain 01:00:55-01:04:45 Problem with Wim Hof’s teachings | Never hyperventilate in water 01:04:46-01:08:44 Wim nearly drowns attempting to swim under ice 01:08:45-01:15:15 Cases of people dying from shallow water blackout 01:15:16-01:17:32 What can the average person take from cold exposure? 01:17:33-01:20:18 The Wedge | A look at sensory and response to sensory 01:20:19-01:22:34 How do I know that you feel what I feel? 01:22:35-01:25:44 We’re isolating ourselves from both the physical and social world 01:25:45-01:28:51 If you want to be comfortable in life you must be uncomfortable at times 01:28:52-01:35:58 Scott’s current and future projects | Scott’s Thoughts Youtube channel, book on napping