Works in Progress Podcast Podcast Por Works in Progress arte de portada

Works in Progress Podcast
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Works in Progress is an online magazine devoted to new and underrated ideas about economic growth, scientific progress, and technology. Subscribe to listen to the Works in Progress podcast, plus Hard Drugs by Saloni Dattani and Jacob Trefethen.Works in Progress Magazine © 2025 Mundial
Episodios
  • Should everyone be taking statins?

    Should everyone be taking statins?
    Feb 27 2026
    Heart disease is the leading cause of death worldwide, but it’s also one of medicine’s biggest success stories. Since the 1950s, the risk of dying from cardiovascular disease has fallen dramatically, thanks to public health efforts, emergency care, medical innovation, and surgeries.In this episode, Jacob and Saloni explore the cholesterol revolution: from statins discovered in fungi to new drugs that cut LDL cholesterol by 60% and last for months, driven by breakthroughs in genetics, monoclonal antibodies, RNA therapies, and modern medicinal chemistry. They talk about how cholesterol travels through the bloodstream, how it causes atherosclerosis and heart disease, and why it took nearly a century for scientists to form the consensus that lowering cholesterol saves lives.Hard Drugs is a podcast from Works in Progress and Coefficient Giving about medical innovation presented by Saloni Dattani and Jacob Trefethen.You can watch or listen on YouTube, Spotify, or Apple Podcasts.Chapters: 0:00:00 Introduction13:35 The decline in heart disease mortality31:02 Surprising facts about cholesterol55:40 The lipid hypothesis: 7 lines of evidence for the harms of LDL cholesterol1:22:15 How cholesterol works1:30:40 The discovery of statins1:48:44 Should everyone be on statins?1:57:10 PCSK9 drugs and beyond2:22:56 Summary Saloni’s substack newsletter: https://www.scientificdiscovery.dev/Jacob’s blog: https://blog.jacobtrefethen.com/ Acknowledgements:Aria Babu, editor at Works in ProgressGraham Bessellieu, video editorAbhishaike Mahajan, cover artAtalanta Arden-Miller, art directionDavid Hackett, composerWorks in Progress & Coefficient GivingBooksDaniel Steinberg (2007) The Cholesterol Wars.Jie Jack Li (2009) Triumph of the Heart: The Story of Statins.Blog postsJames Stein (2025) Lipid and lipoprotein basics series. https://jamesstein18.substack.com/p/part-i-lipid-and-lipoprotein-basics ArticlesAkira Endo (2017) Discovery and Development of Statins https://doi.org/10.1177/1934578X1701200801 Joseph L Goldstein, Michael S Brown (2010) History of discovery: The LDL receptor. https://pmc.ncbi.nlm.nih.gov/articles/PMC2740366/ Patty W. Siri-Tarino and Ronald M. Krauss (2016) The early years of lipoprotein research: from discovery to clinical application https://pubmed.ncbi.nlm.nih.gov/27474223/ Eun Ji Kim and Anthony S. Wierzbicki (2020) The history of proprotein convertase subtilisin kexin-9 inhibitors and their role in the treatment of cardiovascular disease https://pubmed.ncbi.nlm.nih.gov/32537117/ Patrick W. Siri-Tarino et al. (2010) Saturated fat, carbohydrate, and cardiovascular disease. https://www.pnas.org/doi/10.1073/pnas.94.9.4312Saloni Dattani (2025) Death rates from cardiovascular disease have fallen dramatically — what were the breakthroughs behind this? https://ourworldindata.org/cardiovascular-deaths-declineCholesterol Treatment Trialists’ (CTT) Collaboration (2010) Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. https://doi.org/10.1016/S0140-6736(10)61350-5E. J. Mills et al. (2011) Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170,255 patients from 76 randomized trials. https://pubmed.ncbi.nlm.nih.gov/20934984/Julia Brandts and Kausik K. Ray (2023) Novel and future lipid-modulating therapies for the prevention of cardiovascular disease. https://www.nature.com/articles/s41569-023-00860-8 VideosNinja Nerd (2018) Lipoprotein metabolism https://www.youtube.com/watch?v=wQY0xpwqPfQ
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    2 h y 55 m
  • Why Europe has stagnated

    Why Europe has stagnated
    Feb 25 2026

    Europe is now much poorer than America. Is it because Europe doesn’t have a big tech giant? Can we blame the bureaucrats in Brussels? What happened to make Germany ban combustion cars? Should we turn Europe into a playground for American and Asian elites? Are the far right going to solve Europe’s energy problems by burning coal to own the libs? Pieter, Sam and Aria discuss why Europe hasn’t grown very much and what we can do to save it.

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    1 h y 30 m
  • Inflation in Rome, Weimar Germany and Soviet Russia with Mark Koyama

    Inflation in Rome, Weimar Germany and Soviet Russia with Mark Koyama
    Feb 11 2026

    People hate inflation. It undermines faith in the government so people obstruct policies that require faith in the state, like nuclear power, and in democracies it drives them to vote for extremist parties. Ben and Pieter sit down with economic historian Mark Koyama and discuss the fallout of historical inflation crises from the Roman Empire to Weimar Germany. Ben reveals his hidden libertarian 'Gold Bug' tendencies.

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    1 h y 17 m
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