Warfarin (Vitamin K Antagonist; VKA): Pharmacology Made Easy

Warfarin (Vitamin K Antagonist; VKA) doesn’t have to be confusing. In this lecture from This is Why, Dr. Busti will explain warfarin's (Coumadin) pharmacology in a simple, clinically relevant way. It is perfect for anyone reviewing anticoagulation.

You’ll learn how to:
- Mechanism of action: how warfarin works as a vitamin K antagonist (VKA) (VKOR inhibition)
- What PT/INR measures and why INR monitoring matters
- How to start warfarin dosing (and what affects dose response)
- Bridging with heparin/LMWH (warfarin bridge / heparin bridge) and when it’s needed
- High-yield warfarin interactions (CYP2C9 inhibitors/inducers) + vitamin K foods
- Warfarin reversal basics (including vitamin K reversal)

The goal = make medical education easy and clinically relevant.

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Disclaimer:
This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.