Using Nourished Fasting for Metabolic Health and Longevity with Dr. William Hsu

In this episode, Dr. Jockers and Dr. William Hsu dive into how nourished fasting can reduce insulin resistance, activate autophagy, and slow aging. They discuss how the fasting mimicking diet triggers cellular repair while still providing nourishment. Learn how nutrient-sensing pathways like mTOR and IGF-1 influence metabolic health and why modern eating habits may accelerate aging. Dr. Hsu explains how short-term fasting can promote healing by tapping into the body’s natural survival mechanisms. Discover how to apply nourished fasting in your life with the ProLon protocol and why a few cycles a year can significantly improve your healthspan. In This Episode: 00:00 Introduction to the Fast Mimicking Diet 02:49 Interview with Dr. William Hsu: Metabolic Health and Fasting 04:48 The Science Behind Fasting and Cellular Healing 06:49 The Evolutionary Perspective on Fasting 09:22 Understanding Nutrient Sensing Pathways 14:33 The Nobel Prize-Winning Research on Autophagy 17:44 The Concept of Fasting Mimicking Diet 21:25 Exploring the Benefits of Fasting Mimicking Diet 22:01 The Science Behind Fasting and Systemic Health 23:22 The Role of Lifestyle Medicine 24:16 Understanding Digestive Health and Stomach Acid 26:10 Hormetic Stress and Health Benefits 27:16 Clinical Research on Fasting Mimicking Diet 31:32 Practical Application of Fasting Mimicking Diet 32:43 Personalized Programs for Health Conditions 35:22 The Future of Lifestyle Medicine 40:54 Final Thoughts and Call to Action Still cooking with seed oils? That could be fueling inflammation. I’ve switched to Paleovalley’s 100% grass-fed beef tallow—it’s rich in CLA, packed with flavor, and stable at high heat. It’s one of the cleanest, most nutrient-dense fats you can cook with. Head to paleovalley.com/jockers and use code JOCKERS for 15% off your order. Heartburn doesn’t mean you have too much stomach acid—it usually means you don’t have enough. That’s why I recommend Just Thrive’s Digestive Bitters. They help ignite stomach acid, enzymes, and bile so you can finally break down food the way you’re supposed to. Go to justthrivehealth.com and use code JOCKERS to save 20%. "Autophagy is your body’s self-cleaning cycle—and most people never turn it on." ~ Dr. Jockers Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio Resources: Get 15% off Paleovalley Beef Tallow: paleovalley.com/jockers – Use code JOCKERS Save 20% on Just Thrive Digestive Bitters: justthrivehealth.com – Use code JOCKERS Connect with Dr. William Hsu: Website: https://l-nutra.com/portfolio/william-hsu-md/ Prolon 5 Day Fasting Mimicking Diet: https://prolonlife.com/ Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/