Transforming Skin Cells into Neurons to Treat Alzheimer’s with Brendon Boot of Skin2Neuron

Greg and Matias interview Brendon Boot of Skin2Neuron. Brendon is a neurologist at Harvard and Mayo Clinic with prior experience as Medical Director at Biogen overseeing their Phase 1b Alzheimer’s trials.

In this episode, we discuss:

• How skin-derived cells can be turned into neurons to repair the brain.
• Why replacing lost neurons may succeed where drugs have failed in Alzheimer’s.
• What makes autologous (self-derived) cell therapy safer and more effective.
• How testing in dogs brought stronger proof than traditional mouse models.
• Why this approach could shift Alzheimer’s treatment from slowing decline to restoring memory.

Credits:

Created by Greg Kubin and Matias Serebrinsky
Host: Matias Serebrinsky & Greg Kubin
Produced by Caitlin Ner & Nico V. Rey

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Theme music by Dorian Love
Additional Music: Distant Daze by Zack Frank