Thomas Seyfried: The Metabolic Theory of Cancer — Glucose, Glutamine & Anti-Parasitic Drugs

What if cancer isn't primarily a genetic disease — but a metabolic one? In this groundbreaking conversation, Professor Thomas N. Seyfried, PhD (Boston College), author of Cancer as a Metabolic Disease, joins Ralph W. Moss, PhD and Ben Moss to discuss the Mitochondrial and Metabolic Theory of Cancer — and why it challenges decades of conventional thinking. Dr. Seyfried explains how cancer cells depend on glucose and glutamine as their dual fuel supply — and how cutting off both pathways may be the key to shutting cancer down. He details the role of the Glucose Ketone Index (GKI), nutritional ketosis, and new interest in anti-parasitic drugs like fenbendazole and mebendazole, which appear to target cancer's energy metabolism. This episode explores: Why the somatic mutation theory no longer explains cancer's true originHow mitochondrial dysfunction drives tumor growthThe critical role of glucose and glutamine fermentation in sustaining cancer cellsWhy targeting both fuels together is essential for effective therapyEmerging research on fenbendazole, mebendazole, and DON as tools in metabolic therapyThe potential of a paradigm shift in oncology — from genes to metabolism Resources: This Podcast contains many scientific terms. To assist our readers in understanding them, we have created this glossary. The article with links, resources and full transcript can be found here: https://themossreport.com/s5-e13-prof-thomas-seyfried-mitochondrial-metabolic-theory/ Direct link to The Warburg hypothesis and the emergence of the mitochondrial metabolic theory of cancer https://link.springer.com/content/pdf/10.1007/s10863-025-10059-w.pdf In the Journal https://link.springer.com/article/10.1007/s10863-025-10059-w Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis Christos Chinopoulos & Thomas N. Seyfried Paper https://www.tandfonline.com/doi/epdf/10.1177/1759091418818261?needAccess=true (PDF) https://www.tandfonline.com/doi/full/10.1177/1759091418818261 Christos Chinopoulos https://semmelweis.hu/english/2019/09/my-university-dr-christos-chinopoulos-and-the-rppa-facility/ Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma https://pubmed.ncbi.nlm.nih.gov/31149644 Glucose Ketone Index Calculator Post https://pmc.ncbi.nlm.nih.gov/articles/PMC4367849 Spreadsheet with calculator https://pmc.ncbi.nlm.nih.gov/articles/instance/4367849/bin/12986_2015_9_MOESM1_ESM.xlsx Sam Apple - Ravenous https://amzn.to/4nr6YMP 🌿 The Moss Method – Fight Cancer Naturally – (Paperback, Hardcover, Kindle) https://www.amazon.com/gp/product/1881025799/ 📘 The Moss Report Cancer Treatment Guides – https://themossreport.store/guides 📚 Dr. Moss' Full Catalog of Books on Cancer – https://themossreport.store/books/ 🌎 Full Transcript, Research Notes, Articles & Videos – https://www.themossreport.com 🤝 The Moss Report is sponsored by Mycolife.US - Makers of The World's Best Mushroom Extracts, including The Moss Method Mushroom Formula, available exclusively at https://www.mycolife.us/