The Truth About GLP-1s, Weight Loss, and Rebound Gain

You’ve probably heard of GLP-1 drugs like semaglutide and tirzepatide—and maybe you’ve even wondered, “Should I be on one of these?” This conversation is my honest, compassionate take on these powerful weight loss medications: not medical advice, not fear-mongering, and definitely not hype.

In this episode, I unpack what GLP-1 receptor agonists (a class of anorectic drugs) really are, how they work, why they’re so effective for fat loss—and what most people don’t realize about what happens when you stop taking them. I’ll walk through recent research, potential side effects, and the rebound weight gain that happens to so many… not because you failed, but because of basic human physiology.

This is a supportive conversation for anyone who's considering these medications, already using them, or just wants to better understand their role in the weight loss space. And while there’s no shame in using tools like these, lifestyle change still has to be the foundation. Always.

What we go over:

• What GLP-1 drugs actually do in your body
• What happens after you stop taking them (and why)
• Why muscle loss and metabolic slowdown are often overlooked
• The importance of strength training, protein, and movement—even with meds
• Why long-term success still comes down to habits, not just prescriptions
• How to think critically and compassionately about weight loss tools

These drugs are effective—but they’re not magic. Let’s have the real conversation.

Sources:

Quarenghi M, Capelli S, Galligani G, Giana A, Preatoni G, Turri Quarenghi R. Weight Regain After Liraglutide, Semaglutide or Tirzepatide Interruption: A Narrative Review of Randomized Studies. Journal of Clinical Medicine. 2025; 14(11):3791. Weight Regain After Liraglutide, Semaglutide or Tirzepatide Interruption: A Narrative Review of Randomized Studies

Sun Q. (2026). Weight regain after cessation of GLP-1 drugs. BMJ (Clinical research ed.), 392, r2586. https://doi.org/10.1136/bmj.r2586

West S, Scragg J, Aveyard P, Oke J L, Willis L, Haffner S J P et al. Weight regain after cessation of medication for weight management: systematic review and meta-analysis BMJ 2026; 392 :e085304 doi:10.1136/bmj-2025-085304

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Podcast Produced by Virtually You!