The Stem Cell Report with Janet Rossant Podcast Por ISSCR arte de portada

The Stem Cell Report with Janet Rossant

The Stem Cell Report with Janet Rossant

De: ISSCR
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Stem cell science has catapulted to the forefront of biomedical research over the last decade, bringing with it the potential to transform human health and the treatment of devastating diseases and disorders. Janet Rossant, an internationally recognized stem cell pioneer and the dynamic editor-in-chief of Stem Cell Reports, explores basic discoveries in stem cell research and its application. Dr. Rossant goes “beyond the paper,” bringing authors together to draw new insights and explore the questions and creativity that drive new breakthroughs. Stem Cell Reports, published by the International Society for Stem Cell Research (ISSCR), is an open-access, peer reviewed journal that supports the field of stem cell research and regenerative medicine.

© 2026 The Stem Cell Report with Janet Rossant
Ciencia Ciencias Biológicas
Episodios
  • Making Sense of Touch
    Mar 9 2026

    Our guests today created new lab models to study Merkel cells using mouse whisker tissue cultures, mouse skin organoids, and human skin organoids. These models allowed them to study Merkel cells as they develop, validate the role of known signaling pathways, and even identify some new ones. Their work provides easier access to Merkel cells for future studies including disease models to understand the pathophysiology of these cells.

    Guests
    Ying Xiao, PhD, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China
    Chaochen Wang, PhD, Zhejiang University - University of Edinburgh Institute, China
    Huipu Yuan, MD, PhD, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China
    Yajun Zhang, Zhejiang University - University of Edinburgh Institute, China

    Host
    Janet Rossant, Editor-in-Chief, Stem Cell Reports and The Gairdner Foundation

    Supporting Content
    Paper link: An innovative in vitro system unveils IGF1R signaling regulating Merkel cell generation, Stem Cell Reports

    About Stem Cell Reports
    Stem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians. X: @StemCellReports

    About ISSCR
    Across more than 80 countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to advancing stem cell research and its translation to medicine.

    ISSCR Staff
    Keith Alm, Chief Executive Officer
    Shuangshuang Du, Scientific Programs Manager
    Yvonne Fisher, Managing Editor, Stem Cell Reports
    Kym Kilbourne, Director of Media and Strategic Communications
    Megan Koch, Senior Marketing Manager
    Jack Mosher, Scientific Director
    Hunter Reed, Senior Marketing Coordinator

    Más Menos
    46 m
  • Illuminating hPSC-derived Sensory Neurons
    Feb 10 2026

    Human pluripotent stem cells (hPSCs) are transforming the study of biology and disease by enabling scientists to grow large amounts of specific cell types in the lab that were once difficult to obtain. Our guests today focus on improving the derivation and study of sensory neurons, which are sparse and diverse nerve cells near the spine that carry information like pain, touch, or position of the body to the brain. Damage to these neurons or sensory neuropathies, as can happen in diabetes or infections, is estimated to affect millions of people worldwide, yet treatments are limited. To improve the generation of human sensory neurons, the authors developed a genetic toolkit to fluorescently label these individual cells and their subtypes. This approach enables more precise study of these subtypes, their roles in disease, and potentially the development of treatments for sensory neuropathies.

    Guests
    Joriene C. de Nooij, PhD, Department of Neurology, Columbia University, USA
    Eti Malka-Gibor, PhD, Department of Neurology, Columbia University, USA

    Host
    Janet Rossant, Editor-in-Chief, Stem Cell Reports and The Gairdner Foundation

    Supporting Content
    Paper link: Derivation and analysis of human somatic sensory neuron subtypes facilitated through fluorescent hPSC reporters," Stem Cell Reports

    About Stem Cell Reports
    Stem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians. X: @StemCellReports

    About ISSCR
    Across more than 80 countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to advancing stem cell research and its translation to medicine.

    ISSCR Staff
    Keith Alm, Chief Executive Officer
    Shuangshuang Du, Scientific Programs Manager
    Yvonne Fisher, Managing Editor, Stem Cell Reports
    Kym Kilbourne, Director of Media and Strategic Communications
    Megan Koch, Senior Marketing Manager
    Jack Mosher, Scientific Director
    Hunter Reed, Senior Marketing Coordinator

    Más Menos
    35 m
  • Tuning the X
    Jan 22 2026

    Epigenetic regulation of gene expression is an important mechanism in development and disease. N6-methyladenosine (m6A) is one of the most prevalent epigenetic modifications for RNA and has been shown to play critical roles in processes such as embryo development, cancer, and stress responses. Our guests today investigate how m6A regulates X chromosome dosage compensation to ensure proper balance of gene expression from X chromosomes between sexes. X-chromosome dosage compensation is accomplished through two complementary mechanisms. First, X-chromosome inactivation (XCI) silences one of the two X chromosomes in female cells. Second, the remaining active X chromosome is transcriptionally upregulated so that its gene expression levels are balanced with those of the autosomes, a process known as X-to-autosome (X-to-A) compensation. The authors dissect the distinct contributions of m6A RNA methylation to XCI versus X-to-A compensation across multiple embryonic lineages, providing deeper insights into the epigenetic regulation of early development.

    Guests
    Srimonta Gayen, PhD, Department of Developmental Biology and Genetics, Indian Institute of Science, India

    Host
    Janet Rossant, Editor-in-Chief, Stem Cell Reports and The Gairdner Foundation

    Supporting Content
    Paper link: "The role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages," Stem Cell Reports

    About Stem Cell Reports
    Stem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians. X: @StemCellReports

    About ISSCR
    Across more than 80 countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to advancing stem cell research and its translation to medicine.

    ISSCR Staff
    Keith Alm, Chief Executive Officer
    Shuangshuang Du, Scientific Programs Manager
    Yvonne Fisher, Managing Editor, Stem Cell Reports
    Kym Kilbourne, Director of Media and Strategic Communications
    Megan Koch, Senior Marketing Manager
    Jack Mosher, Scientific Director
    Hunter Reed, Senior Marketing Coordinator


    Más Menos
    43 m
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