What will AI and clinical trials look like in the year 2030? Mike Sullivan, head of IT globally for development operations at Bristol Myers Squibb, joins The Scope of Things to discuss how creating value with AI depends on redesigning how clinical operations teams work. He covers the four pillars of what AI and clinical operations can look like in the next few years, as well as how AI will affect the job market. Plus, host Deborah Borfitz gives you the latest rundown on building the capacity to collaborate with patients, a new playbook for pediatric clinical trial reporting, lithium treatment for verbal memory decline, sex-specific effects of dementia, open-source database for scaling cancer trials, and a proposed 10-year trial of anti-obesity drugs for preventing obesity-related cancers.

Show Notes

News Roundup

Power dynamics in researcher-patient relationships

• Study published in Health Expectations

Playbook forpediatricclinical trial reporting

• Statement on reporting protocols published in The BMJ
• Statement on reprintng completed trials published in The BMJ

Low-dose lithium for slowing verbal memory decline

• Study in JAMA Neurology
• News on the University of Pittsburgh Medical Center website

Parkinson's-related protein linked to faster Alzheimer's progression in women

• Study in JAMA Network Open
• Press release on the Mayo Clinic website

AstroID database for studying cancer

• Study in Journal for Immunotherapy of Cancer
• News release on the Johns Hopkins website

Anti-obesity drugs for preventing cancer

• News release from the European Congress on Obesity

Guest

Mike Sullivan, head of IT globally for development operations at Bristol Myers Squibb

The Scope of Things podcast explores clinical research and its possibilities, promise, and pitfalls. Clinical Research News senior writer, Deborah Borfitz, welcomes guests who are visionaries closest to the topics, but who can still see past their piece of the puzzle. Focusing on game-changing trends and out-of-the-box operational approaches in the clinical research field, the Scope of Things podcast is your no-nonsense, insider’s look at clinical research today.

How can electronic capture of clinical outcome assessments (eCOA) help with the unique challenges of pediatric rare disease trials? Florence Mowlem, chief scientific officer of uMotif, joins The Scope of Things to offer her expertise on eCOA, share advice for companies on vetting technology providers, and discuss where sponsors are tripping up when it comes to pediatric rare disease trials. Plus, host Deborah Borfitz brings you the latest news on a possible probiotic for preventing immune system disorders in babies, misunderstood mechanisms of body weight regulation, a promising primary care-based weight management program, GLP-1 drugs potentially benefitting the brain, how patient-reported outcomes can improve clinician adverse event reporting, and a discovery-to-reimbursement model for cell and gene therapies.

Show Notes

News Roundup

Preventing allergies and asthma

• Study in Nature Microbiology
• News from the Technical University of Denmark

Competing body weight regulation theories

• Study in Nature Reviews Endocrinology
• News on the Pennington Biomedical Research Center website

PATHWEIGH weight management process

• Pragmatic study in Nature Medicine
• News on the University of Colorado Anschutz website

Diabetes drugs reduce risk of dementia

• Study in Drug Safety
• News on McGill University website

PRO data improved side effect grading

• Study in The Lancet Oncology
• Blog post on EORTC website

Development model for cell and gene therapies

• Research article in Molecular Therapy, Methods and Clinical Development
• News on the Lund University website

Guest

Florence Mowlem, chief scientific officer at uMotif

The Scope of Things podcast explores clinical research and its possibilities, promise, and pitfalls. Clinical Research News senior writer, Deborah Borfitz, welcomes guests who are visionaries closest to the topics, but who can still see past their piece of the puzzle. Focusing on game-changing trends and out-of-the-box operational approaches in the clinical research field, the Scope of Things podcast is your no-nonsense, insider’s look at clinical research today.

Joining this month’s episode of The Scope of Things is Joseph Kim, chief strategy officer of ProofPilot, who talks about his company’s first-ever CORE Symposium, where pharma pros shared practical solutions to age-old trial challenges. Kim provides a pragmatic viewpoint on the problematic trio of clinical trials—study execution, recruitment, and engagement—and what change agents are needed to pave the way forward and find an exit from the bottlenecks. Plus, host Deborah Borfitz delivers the latest on a planned mapping of clinical trial deserts, the high cost of accelerated FDA approvals, the best states for cancer research, the world’s first in-ear EEG system getting approved, and a new smartphone-based outcome measure for sleep studies.

News Roundup

Financial hurdles to trial enrollment

• Study in the Journal of the National Comprehensive Cancer Network
• News on the Case Western Reserve University website

Accelerated cancer drug approvals

• Study in BMJ Medicine

Best states for cancer research

• Blog on SmileHub website

In-ear EEG devices

• Article in Diagnostics World News

Ecological momentary assessment in sleep-focused trial

• Study in JAMA Network Open

Guest

Joseph Kim, chief strategy officer for ProofPilot

The Scope of Things podcast explores clinical research and its possibilities, promise, and pitfalls. Clinical Research News senior writer, Deborah Borfitz, welcomes guests who are visionaries closest to the topics, but who can still see past their piece of the puzzle. Focusing on game-changing trends and out-of-the-box operational approaches in the clinical research field, the Scope of Things podcast is your no-nonsense, insider’s look at clinical research today.