The Schizophrenia Puzzle is Solvable | W. Gordon Frankle, MD, MBA

There’s a care model for schizophrenia that actually works—why isn’t it everywhere? On this episode, W. Gordon Frankle, MD, MBA, Vice Chair of Psychiatry at NYU Langone Health, shares how his team in Brooklyn is building a new model for treating serious mental illness—one rooted in long-term, relationship-driven, team-based care. From wraparound services to precision psychiatry, this conversation explores what happens when you bring humanity, structure, and innovation to a population too often left behind.

Also discussed:

• The first novel schizophrenia drug in over 50 years (Cobenfy)
• Why clozapine is underused—and how that may finally change
• The potential of brain imaging and biomarkers in psychiatric treatment
• What a real community mental health system looks like
• Why trust, not just treatment, is essential for recovery

🔍 Topics Covered

00:00 Introduction
00:30 Dr. Frankle's Current Work
01:08 Advancements in Schizophrenia Research
02:29 Challenges and New Treatments in Schizophrenia
05:02 Precision Medicine in Psychiatry
05:59 PET Scans and Brain Energetics
09:46 Barriers to Effective Treatment
11:51 Clozapine and Treatment Access
13:38 Wraparound Services and Community Care
14:46 Early Screening and Public Health Interventions
18:32 Mandated Treatment and Patient Engagement
30:08 Homelessness and Mental Health
34:54 Future Directions in Schizophrenia Treatment
38:09 Conclusion

📚 Related Resources

W. Gordon Frankle, MD, MBA
Schizophrenia care at NYU Langone
NYU Langone Hospital—Brooklyn
3 Things to Know About Cobenfy (Yale Medicine)

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Executive Producer: Jon Earle