The Metabolic Storm of Menopause and HRT Timing for Fat Loss & Muscle (Karen Martel) | Ep 382

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What if waiting too long for hormone therapy meant more than hot flashes? What if it set you up for stubborn weight gain, bone loss, and low energy?

I talk with hormone specialist Karen Martel about why timing matters for HRT, how hormone shifts impact metabolism, muscle, and mood, and why lifestyle alone isn’t always enough. We cover genetics, trauma, and the latest tools, from HRT to GLP-1s—that can help women reclaim vitality in midlife and beyond.

Karen Martel is the host of The Hormone Solution Podcast, where she helps women thrive through perimenopause and menopause with practical, science-backed solutions.

Today, you’ll learn all about:

6:35 – How hormones trigger a metabolic storm
12:56 – The rise of belly fat and insulin resistance
19:11 – Muscle, bone, and recovery challenges
23:51 – Life without hormone therapy
28:55 – Key tests to watch in your 40s
44:12 – GLP-1s as a new tool
59:17 – A positive future for women’s health

Episode resources:

• Karen’s Bioidentical Hormone Products (Creams & Oils) - use code WITSANDWEIGHTS for 10% off
• Karen’s group hormone coaching

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