The How and Why of Sleep: Motor Theory and Catecholamine Hypothesis
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The How and Why of Sleep: Motor Theory and Catecholamine Hypothesis
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In this episode, we explore a groundbreaking 2025 Neuron paper that reframes how sleep is generated in the brain, and why we sleep at all.
Instead of a single “sleep centre,” sleep emerges from a distributed network embedded within motor and autonomic circuits. The authors also propose a unifying “catecholamine hypothesis” explaining sleep’s restorative functions across brain, immune, and metabolic systems.
We break down what this means for clinicians, how it updates classic models of sleep–wake regulation, and why dysfunction in these systems manifests across psychiatry.
To access all episodes of this podcast plus 150+ hours of advanced psychiatric education, join the Academy today. Get access here:
https://www.academy.psychscene.com/