In this episode, we unpack the Interstitial Inflammatory Stasis (IIS) hypothesis introduced by Tuckey et al. (2021) in Frontiers in Pain Research. The authors propose that after injury or immune activation, inflammation can become “trapped” within the body’s microscopic fluid channels creating a self-perpetuating loop of congestion, fascial tension, and pain.

You’ll learn how this model integrates existing pain theories into one fascia-based framework. We’ll also explore how these ideas align with occupational therapy practice: restoring interstitial flow through movement, breath, manual therapy, and autonomic regulation.

Join the fascia-informed conversation: The Fascia-Informed Therapist ™ - Grounded in science. Practicing on the cutting edge.

References

Benias, P. C., Wells, R. G., Sackey-Aboagye, B., Klavan, H., Reidy, J., Buonocore, D., Miranda, M., Kornacki, S., Wayne, M., Carr-Locke, D. L., & Theise, N. D. (2018). Structure and Distribution of an Unrecognized Interstitium in Human Tissues. Scientific reports, 8(1), 4947. https://doi.org/10.1038/s41598-018-23062-6

Tuckey, B., Srbely, J., Rigney, G., Vythilingam, M., & Shah, J. (2021). Impaired Lymphatic Drainage and Interstitial Inflammatory Stasis in Chronic Musculoskeletal and Idiopathic Pain Syndromes: Exploring a Novel Mechanism. Frontiers in pain research (Lausanne, Switzerland), 2, 691740. https://doi.org/10.3389/fpain.2021.691740

If you’ve ever had a loved one in the hospital, you know the range of emotions that comes with it including fear, frustration, hope, and gratitude, often all at once. In this episode, I share my personal experience navigating my father’s recent hospitalization for an acute illness (on top of a long-term disability) and what it has reminded me about the human side of healthcare. When we take the time to truly see and understand our patients including their history, their challenges, their stories, we can provide care that is not just skillful, but compassionate. This episode is both a reflection and a reminder of why understanding and empathy must remain at the heart of our fascia-informed practice.

Join the conversation: The Fascia-Informed Therapist ™ - Grounded in science. Practicing on the cutting edge.

In this episode, we explore compartment syndrome (CS), a condition where pressure builds within the body’s muscular compartments, restricting blood flow, causing pain and threatening tissue health. You’ll learn the difference between acute and chronic (exertional) forms, how fascia’s properties play a role in pressure dynamics, and what recent research says about both surgical and conservative management. We'll also discuss the role habits may play in the development and management of CS as I share experiences with my own clients.

Whether you work in orthopedics, rehabilitation, or wellness, this episode highlights the types of CS and how understanding fascia can help you better educate your client and perhaps even your referral sources.

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• Cleveland Clinic. Compartment Syndrome Overview.

• StatPearls. Exertional Compartment Syndrome – NCBI Bookshelf.

• Elsenosy, A. M., Elnewishy, A., Hassan, E., & Delewar, R. A. (2024). Outcomes of Fasciotomy Versus Conservative Management for Chronic Exertional Compartment Syndrome: A Systematic Review and Meta-Analysis. Cureus, 16(12), e75803. https://doi.org/10.7759/cureus.75803

• Altan, L. (2023). Postoperative Rehabilitation of Compartment Syndrome Following Fasciotomy. Turkish Journal of Physical Medicine and Rehabilitation, 69(2), 133–139. https://doi.org/10.5606/tftrd.2023.13041

• Schleip, R., & Wilke, J. (2023). Fascia in Sport and Movement. Handspring Publishing.