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Talking Ketamine Podcast

Talking Ketamine Podcast

De: Talking Ketamine
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Explore the cutting-edge science and therapeutic potential of ketamine. Talking Ketamine offers evidence-based discussions to demystify its role in mental health and beyond, providing informed insights into this powerful compound.© 2025 Talking Ketamine Ciencia Ciencias Biológicas Higiene y Vida Saludable Medicina Alternativa y Complementaria Psicología Psicología y Salud Mental
Episodios
  • The Electrodynamics of Ketamine

    The Electrodynamics of Ketamine
    Oct 17 2025
    This episode breaks down a truly radical theory of consciousness: The General Resonance Theory (GRT). Forget the traditional idea that consciousness comes from synapses firing—GRT proposes that it emerges from near-instantaneous, resonant electromagnetic field interactions within the brain, moving information up to 40,000 times faster than slow neuronal spikes. This electrical "field" is the true substrate of our unified sense of reality. We use this theory to answer the biggest question in psychedelic science: Why does ketamine cause dissociation? While classic psychedelics are seen as "field resonance enhancers" that create feelings of unity and global synchronization, ketamine does the precise opposite. We reveal the precise mechanism: ketamine preferentially removes the "brakes" (NMDA receptors on inhibitory GABA neurons). This results in fragmented hyperactivity. Local circuits go wild, but they lose the coherence needed for a unified sense of self, leading to the subjective experience of dissociation and the ultimate breakdown of integrated consciousness—the K-hole. Electrically, this shows up as a measurable decoupling between the frontal and parietal regions, the key areas for self and spatial awareness. Finally, we explore the provocative idea that ketamine's rapid antidepressant effect might be due to this temporary, total electromagnetic reset—a complete shaking of the "snow globe" that forces the brain's rigid, unhealthy field patterns to resettle into a more flexible configuration. This is mind-bending physics that reframes mental health treatment as an exercise in tuning the brain’s frequency. Reference: Hunt, T. (2025). Electrodynamics of the Psychedelic Experience. Preprints.org. https://doi.org/10.20944/preprints202509.1813.v1
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    12 m
  • Ketamine and Stroke Recovery

    Ketamine and Stroke Recovery
    Oct 9 2025
    When stroke strikes, the damage doesn't stop once the blood flow is restored. This episode dives into the dark side of recovery: the Ischemia-Reperfusion (IR) Injury, a devastating "second wave" of damage that causes lasting neurological deficits. We explore a fascinating preclinical study on esketamine, the S-enantiomer of ketamine. Researchers hypothesized that this powerful NMDA receptor antagonist could stop IR injury, which is fueled by excessive excitotoxicity. We reveal how esketamine, when administered immediately after blood flow is restored, actively helps the brain fight back. The findings are compelling: esketamine significantly reduced markers of cell membrane damage (MDA) and, crucially, bolstered the brain’s own antioxidant defense system in the vulnerable hippocampal CA1 region. This dose-dependent effect points toward a new therapeutic window, allowing intervention hours or even days after a clot is removed. Could ketamine be the neuroprotectant that finally helps save the tissue we just rescued? Tune in to understand the science behind this potential breakthrough and the challenge of finding the neuroprotective 'sweet spot' dose. Reference: Erfani, S., Amirhaidari, B., & Khoshnazar, S. M. (2025). Antioxidant Therapeutic Potential of S-Ketamin Against Cerebral Ischemia/Reperfusion Injury in Male Rats. Journal of Isfahan Medical School, 43(821), 749–758. https://doi.org/10.48305/jims.v43.i821.0749
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    10 m
  • Ketamine and the Aging Brain

    Ketamine and the Aging Brain
    Oct 3 2025
    When traditional antidepressants fail older adults with treatment-resistant depression, where can they turn? Standard therapies, built on the monoamine hypothesis, often fall short in aging brains or those affected by neurodegenerative diseases like Alzheimer's, as the pathways they rely on may be dysfunctional. This episode dives deep into a systematic review exploring a paradigm-shifting alternative: ketamine and its derivatives, esketamine and arketamine. These compounds sidestep conventional mechanisms, instead targeting the NMDA receptor to promote widespread neuroplasticity. We uncover the powerful clinical findings, revealing that ketamine provides rapid, robust relief and is equally effective in geriatric and non-geriatric populations. Discover how ketamine not only improves mood but also restores vital executive functions, helping patients think more clearly. We'll explore the neurological data showing how the treatment restores the brain's crucial "excitation-inhibition" balance, leading to more organized cognitive processing. While the immediate benefits are profound, we also confront the critical unresolved question of long-term sustainability. Join us to understand how this research challenges us to move beyond targeting single chemicals and toward therapies that aim to rebuild the entire circuitry of the mind.
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    14 m
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