World Habitat Day is marked on the first Monday of October each year and is recognized by the United Nations to reflect on the state of towns and cities, and on the basic right of all to adequate shelter.

On 6 October 2025, the Global Observance of World Habitat Day will be linked to urban crisis response. The theme focuses on addressing multiple crises affecting urban areas - including climate and conflicts - that are contributing to inequality, and promotes existing tools and approaches to effective crisis response.

The day will highlight sustainable, scalable, and transformative solutions to urban displacement that help stabilize populations, while promoting prosperity and fostering social cohesion for all. It will put the spotlight on the importance of urban and territorial planning, inclusive urban governance, and the role of local governments in sustainable solutions for displacement.

October is the tenth month of the year in the Julian and Gregorian calendars. Its length is 31 days. The eighth month in the old calendar of Romulus c. 750 BC, October retained its name (from Latin and Greek ôctō meaning "eight") after January and February were inserted into the calendar that had originally been created by the Romans. In Ancient Rome, one of three Mundus patet would take place on October 5, Meditrinalia October 11, Augustalia on October 12, October Horse on October 15, and Armilustrium on October 19. These dates do not correspond to the modern Gregorian calendar. Among the Anglo-Saxons, it was known as Winterfylleth (Ƿinterfylleþ), because at this full moon, winter was supposed to begin.[2]

October is commonly associated with the season of autumn in parts of the Northern Hemisphere, and spring in parts of the Southern Hemisphere, where it is the seasonal equivalent to April in the Northern Hemisphere and vice versa.

Inactivation of p53 functions is an almost universal feature of human cancer cells. This has spurred a tremendous effort to develop p53 based cancer therapies. Gene therapy using wild-type p53, delivered by adenovirus vectors, is now in widespread use in China. Other biologic approaches include the development of oncolytic viruses designed to replicate and kill only p53 defective cells and also the development of siRNA and antisense RNA's that activate p53 by inhibiting the function of the negative regulators Mdm2, MdmX, and HPV E6. The altered processing of p53 that occurs in tumor cells can elicit T-cell and B-cell responses to p53 that could be effective in eliminating cancer cells and p53 based vaccines are now in clinical trial. A number of small molecules that directly or indirectly activate the p53 response have also reached the clinic, of which the most advanced are the p53 mdm2 interaction inhibitors. Increased understanding of the p53 response is also allowing the development of powerful drug combinations that may increase the selectivity and safety of chemotherapy, by selective protection of normal cells and tissues.Thirty years of research on p53 have produced a detailed understanding of its structure and function. The almost universal loss of p53 activity in tumors has spurred an enormous effort to develop new cancer treatments based on this fact. Sophisticated animal models have shown that activation of the p53 response in even advanced tumors can be curative (Martins et al. 2006; Ventura et al. 2007; Xue et al. 2007). The p53 gene therapy, Gendicine, is approved in China and its US counterpart, Advexin, has shown activity in number of clinical trials. The p53 protein level is raised in many tumors by virtue of an increase in the protein's half life and this tumor specific alteration in p53 processing has attracted tumor immunologists, who are now testing a number of p53 based vaccines in cancer patientsIn more conventional approaches a range of small druglike molecules targeting the p53 system have been developed and several are now in clinical trials. Of critical importance has been the development of small-molecule inhibitors of the p53–Mdm2 protein interaction such as the Nutlins (Vassilev et al. 2004), which have shown activity against human xenografts in preclinical models. Advanced structural approaches have provided compelling support for the idea that some mutant p53 proteins can be targets for small molecules that would cause them to regain wild-type function (Joerger et al. 2006). Cell based screening methods have identified small molecules that can activate both mutant and wild-type p53 proteins in tumor cells to induce apoptosis. These screens, and RNAi based approaches, have revealed many new targets for therapy in the p53 pathway. In an exciting new approach, that has been validated in other tumor suppressor pathways, the search is on for targets in pathways that will show synthetic lethal interactions with loss of p53 function. Finally drug combinations have been developed that can selectively kill cancer cells that lack p53 function while protecting normal cells (Sur et al. 2009). The next few years hold out the prospect of new p53 based therapies that will be of wide application in cancer and other diseases.

Defects of kids' makeup include allergic reactions, such as hives and blisters, due to ingredients like chromium and cobalt. Toxic chemicals like lead and cadmium are found in high concentrations in some products, causing developmental issues and increasing cancer risk. Cosmetics can also lead to early puberty in girls due to endocrine-disrupting chemicals and may cause psychological damage by promoting unhealthy beauty ideals.

“You’re beautiful just the way you are.”

A phrase we’ve all heard from our parents, and it’s always true of course! But right now, chances are your child is being exposed online, at their friends’ house or at school to endless products that promote beauty or other kinds of visual transformation.

And let’s face it, even a parent’s sincere compliment can’t always compete with the allure of the steady stream of marketers and influencers pushing gleaming lip-gloss, colorful characters and virtual perfection. (At least that 1980’s bright blue glitter eyeshadow trend is gone and more natural styles are in!)

While interest in makeup begins at a young age and tends to rise in middle school when kids engage in character-play and emulate older children and adults, parents may wonder what age is appropriate to allow their kids to wear makeup. Parents may also wonder how to keep kids safe and healthy once they do decide to allow it.

“The first rule of thumb is to have an open discussion about makeup as soon as your child expresses interest,” says pediatrician Eva Kubiczek-Love, MD. “As with any new activity as your kids grow, parents need to establish expectations, set limits and understand the psychological and health impact of these permissions on them.”

Water Bottle usage#AVOID PLASTICS#POLLUTION#CAUTION#WATER BOTTLE#DAILY USE#CLEAN#RECYCLE#EDUCATIONAL#CREATER-SARAVANANARUNACHALAMA water bottle is a container that is used to hold liquids, mainly water, for the purpose of transporting a drink while travelling or while otherwise away from a supply of potable water. Water bottles are usually made of plastic, glass, or metal.

10 Reasons to Take A Reusable Water Bottle Everywhere

In this blog, we will explore ten compelling reasons why taking a reusable water bottle everywhere should be a part of your lifestyle.

Reduce Plastic Waste: By using a reusable water bottle, you can significantly reduce the amount of plastic waste generated from single-use plastic bottles. Every year, millions of plastic bottles end up in landfills and oceans, contributing to pollution and harming marine life. By carrying your own water bottle, you can make a positive impact and help combat the plastic waste crisis.

Save Money: Investing in a reusable water bottle is a smart financial decision. Instead of continuously buying bottled water, you can refill your reusable bottle with tap water, which is significantly cheaper. Over time, this simple switch can lead to substantial savings.

Stay Hydrated Anytime, Anywhere: Having a reusable water bottle with you ensures that you can stay hydrated throughout the day. Whether you’re at work, traveling, or engaged in outdoor activities, having access to clean, fresh water can improve your overall well-being and help you maintain optimal hydration levels.

Environmental Conservation: By choosing a reusable water bottle made from sustainable materials like stainless steel or glass, you are actively participating in environmental conservation. These materials have a lower environmental impact compared to plastic and can be recycled or repurposed, reducing resource consumption and pollution.

Healthier Alternative: Plastic bottles can contain harmful chemicals like BPA (bisphenol A), which can leach into the water and have adverse effects on human health. By using a reusable water bottle made from safe materials, like stainless steel water bottles you can ensure that you’re consuming water free from potential contaminants.

Customization and Style: Reusable water bottles come in a wide range of designs, colors, and sizes, allowing you to choose one that reflects your personality and style. You can even personalize them with stickers or engravings, making it a unique accessory that you can proudly carry with you.

Encourage Sustainable Practices: Carrying a reusable water bottle sends a powerful message to others about the importance of sustainable practices. It can inspire your friends, family, and colleagues to adopt similar habits, leading to a collective effort in reducing plastic waste and promoting eco-friendly choices.

Convenient and Easy to Use: Reusable water bottles are designed to be practical and user-friendly. They often feature leak-proof lids, easy-to-carry handles, and wide-mouth openings for effortless filling and cleaning. Their durability ensures they can withstand daily use and even survive accidental drops.

Versatile and Multipurpose: Reusable water bottles can serve various purposes beyond holding water. They can accommodate hot beverages like tea or coffee, allowing you to carry your favorite drink wherever you go.

Be Part of the Solution: By taking a reusable water bottle everywhere, you become an advocate for sustainable living. Your actions inspire others and contribute to the collective effort of building a greener future. It’s a small change that can make a big difference in reducing waste and conserving resources.