Squamous Cell Carcinoma of the Anal Canal — An Interview with Dr Marwan Fakih (Companion Faculty Lecture)

Featuring a slide presentation and related discussion from Dr Marwan Fakih, including the following topics:

• Overview of etiology, incidence and staging of squamous cell cancer of the anal canal (SCAC) (0:00)
• Systemic therapy approaches to the management of recurrent unresectable and metastatic SCAC (6:17)
• Available data with anti-PD-1 (pembrolizumab, nivolumab, retifanlimab) and anti-CTLA-4 (ipilimumab) agents in the management of unresectable metastatic SCAC previously treated with chemotherapy (12:59)
• Immunotherapy combined with chemotherapy for the front-line treatment of SCAC (20:48)
• Efficacy and safety of retifanlimab combined with carboplatin/paclitaxel as first-line treatment for SCAC in the Phase III POD1UM-303 trial (23:43)

CME information and select publications