By uncovering critical sex-based differences related to brain and metabolic health, researchers Gillian Einstein and Minna Woo are making the case that tailored interventions are key to improving health outcomes for women — and everyone else. Through their work exploring how conditions from Alzheimer’s to kidney disease can have varied effects depending on a patient’s sex, they underscore what the medical community as a whole can learn from experts in women’s health: Things aren’t as simple as we want to believe. In this bonus episode, recorded live on May 8, 2025, at the MaRS Impact Health Conference, Einstein and Woo discuss the complexity of biology, the challenges of funding and why they’re optimistic that things are changing.

Featured in this episode:

Gillian Einstein is the Wilfred and Joyce Posluns Chair in Women’s Brain Health and Aging and a psychology professor of psychology at the University of Toronto. She’s also an adjunct scientist at Baycrest and Women’s College Hospitals, and an honorary doctor of medicine at Linköping University, Sweden. Her lab’s current focus is on estradiol loss as well as how stigma and immigration affect memory and cognition in diverse populations of women.

Minna Woo is currently the director of the Banting and Best Diabetes Centre at the University of Toronto and recently completed a 10-year term as division director of endocrinology and metabolism at the Toronto General Hospital, University Health Network (UHN). She now holds the Ajmera Chair in Molecular Diabetes Research at the Toronto General Hospital Research Institute and is a clinician scientist and a staff endocrinologist providing diabetes and endocrine care at UHN. Her laboratory focuses on molecular mechanisms that determine the pathogenesis of insulin resistance and related diseases. She has published more than 100 research articles and her research is internationally recognized as a member elect of the American Society of Clinical Investigation.

Katherine Ward is an award-winning journalist currently working with Global News in Toronto. She joined the team in 2018 and has covered a wide range of stories taking her all over Ontario. This year, Ward was also part of an investigative team that exposed the prevalence of lead contamination in drinking water. “Tainted Water” went on to win a national award with Canada’s Radio Television Digital News Association.

Further reading:

• From body to brain: Understanding how sex and gender contribute to brain health as we age
• More women get Alzheimer’s than men. It may not just be because they live longer
• Sleep quality and the menstrual cycle
• Breaking down sex and gender barriers in search of precision medicine
• Canada accelerates diabetes research

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Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.

Extreme heat waves are anything but normal, but they’re quickly becoming the new reality. The 10 hottest years on record have all happened in the last decade. And because temperatures in urban centres can be 10 to 15 degrees Celsius higher than surrounding areas, cities can be dangerous places to be when the mercury rises — particularly for the elderly, those with pre-exisiting health conditions as well as poorer populations who lack access to air conditioning. “Heat has a way of going through the city and finding those who are the weakest,” says Eleni Myrivili, the United Nations’ global heat officer. “It’s a very unfair climate condition.” In this episode, we explore the growing risk posed by heat and what could help us adapt to a hotter world.

Eleni Myrivili is the United Nation’s first-ever global chief heat officer. An anthropologist by training, Myrivili understands how heat waves discriminate against older, less-wealthy and under-served demographics. Before being named to her UN post in 2022, Myrivili was Athens’ heat officer, where she coordinated the capital’s response to heat waves and helped renovate an ancient Roman aqueduct to bring water into the city.

Further reading:

• What will it take to save our cities from a scorching future
• Earth’s 10 hottest years on record are the last 10
• Extreme heat is deadlier than hurricanes, floods and tornadoes combined
• Heat inequality ‘causing thousands of unreported deaths in poor countries’
• The heat crisis is a housing crisis
• Ancient civilizations countered extreme heat. Here’s what cities borrow from history
• Toronto's getting hotter. Experts say a chief heat officer could help the city adapt
• Architects turning to India’s lattice-building designs to keep buildings cool without air conditioning
• How India’s lattice buildings cool without air conditioning
• Athen’s answer to a water supply crunch: an ancient aqueduct

Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.

Experts are calling antimicrobial resistance the silent pandemic: Each year, AMR is responsible for more than a million deaths around the world. It’s a threat to our health that’s been exacerbated by the very medications used to treat it. This problem has been growing for decades, and healthcare practitioners have responded by developing new antibiotics. “And then,” says Dr. Scott Weese, a global expert in antimicrobial resistance, “we started running out of antibiotics.” To address the rise of drug-resistant pathogens, we need to examine how we use these medications to treat disease in both humans and animals, says Weese. The question is, how can we safeguard the life-saving drugs we have — while also protecting the health of all creatures on this planet?

Featured in this episode:

Dr. Scott Weese is a veterinary internal medicine specialist, chief of infection control and director of the Centre for Public Health and Zoonoses at the University of Guelph’s Ontario Veterinary College. Weese is a member of the Global Leaders Group on antimicrobial resistance and has helped craft antimicrobial use guidelines for veterinarians in Canada.

Further reading:

• The global threat of antibiotic resistance
• At the UN, world leaders are negotiating the biggest health issue you’ve never heard of
• Three million child deaths linked to drug resistance, study shows
• Do I need that antibiotic?
• Veterinary medicine is key to overcoming antimicrobial resistance
• The link between pets, people and antimicrobial resistance
• Canada introduces new guidelines to tackle antimicrobial resistance

Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.

Modern medicine has a dirty secret. While plastics have revolutionized healthcare, research increasingly shows that they’re also making us sick. Items such as PPE, syringes, gowns, IV bags and protective wrappings have allowed for a higher standard of sanitary patient care that vastly reduces the risk of cross-contamination. But all that plastic is adding up. Nearly a third of healthcare waste is plastics, and a report on 110 Canadian hospitals revealed the combined waste adds up to 87,000 tons of waste each year. These items break down into microplastics, which accumulate in our bodies and contribute to neurodegenerative, reproductive and overarching health problems. But what will it take to reimagine healthcare without plastic?

Featured in this episode:

• Journalist Susan Freinkel is the author of Plastics: Toxic A Love Story, a book that traces the history of plastics through eight different objects, from the Frisbee to the IV bag, and examines how plastic negatively affects our lives.
• Dr. Ted Schettler is a physician and expert on the health risks of plastics and phthalates. He’s the scientific advisor at Health Care Without Harm, an organization that has dedicated more than 30 years to reducing healthcare’s environmental impact, including the removal of mercury from medical devices.
• An anesthesiologist for more than 20 years, Dr. Lyndia Dernis has seen first-hand the amount of plastic waste operating rooms produce. Currently practicing at St. Mary’s Hospital Centre in Montreal, Dernis has spearheaded the Anesthesia and Environment Committee, which has drastically reduced and recycled the hospital’s plastic waste since being implemented in 2020.
• Rashmi Prakash is the CEO of Aruna Revolution, a Halifax-based startup producing sustainable menstrual products. She’s also an adjunct professor at UBC, where she teaches a course on the impact of biomedical engineering on society, sustainability and environmental stewardship. As a biomedical engineer, Prakash has seen the surplus use of single-use plastic medical devices wrapped in single-use plastics, the layers of which she likens to a Russian doll.
• Aditi Sitolay is a masters student of medical device design and entrepreneurship at Imperial College London. She’s also the founder of Synoro Med, a Vancouver-based startup that specializes in designing sterile, reusable medical devices, including an early-prototype IV bag.

Further reading:

• Solving healthcare’s emissions problem
• Your brain could have a spoon’s worth of microplastics. Here’s what to do about it
• We tested our blood for microplastics. This is what we found
• Microplastics: Are we facing a new health crisis — and what can be done about it?
• Prescription for plastic medical waste: How hospitals, medical suppliers are aiming to be greener

Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.

The wildfire that devastated Fort McMurray in 2016 burned more than 579,000 hectares of land, drove 88,000 people from their homes and caused nearly $10 billion in damages. It’s often seen as an outlier, a freak natural disaster. But extreme wildfires, like those that tore through Los Angeles earlier this year, are becoming more intense and harder to control. “We all saw the smoke, and too many of us have seen the fire,” says John Vaillant, author of Fire Weather: The Making of a Beast. “Weather is different now, and fire is different now.” Hotter, drier weather is turning our forests into kindling, and emergency responders are struggling to handle our new reality: intense, unpredictable fires fuelled by a changing climate. In this special episode, host Manjula Selvarajah sits down with Vaillant to better understand how we got here and to see if there is any way out.

Featured in this episode:

John Vaillant is a Vancouver-based author and freelance journalist. His latest work, the Pulitzer Prize–nominated Fire Weather: The Making of a Beast, chronicles how the 2016 Fort McMurray wildfire turned entire neighbourhoods into firebombs and destroyed 2,400 homes and businesses.

Further reading:

• Forged by fire: Fort McMurray 5 years after the disaster
• Canada needs to get ready for a future fraught with fire: How can the forest sector respond?
• FACT SHEET: Climate change and wildfires
• Canada’s 2023 wildfires emitted more carbon than most countries
• Landscapes turned into hellscapes, shock and the ongoing fight against wildfires in Los Angeles
• Los Angeles wildfires magnify California’s “insurance crisis” as homeowners face billions in losses

Subscribe to Solve for X: Innovations to Change the World here. And below, find a transcript to “Fire alarm: Rethinking innovation in an increasingly volatile world.” This interview was recorded at MaRS Climate Impact on December 4, 2024.

Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.

Can AI unravel the mysteries of human biology? Could it help design specialty treatments and cures for disease? Geoffrey von Maltzahn and his team at Generate:Biomedicines are bullish on both counts. AI has greatly accelerated progress in genome engineering, bioengineering and nanotechnology and they are getting closer to developing tailored therapeutics. “Six years ago, this was a crazy idea,” he says. “We’re now convinced that 100 percent of protein therapeutics are going to get created this way.” In this special episode of Solve for X, host Manula Selvarajah sits down with von Maltzahn to talk about where the science is now and where it is headed.

Featured in this episode:

Geoffrey von Maltzahn, general partner of Flagship Pioneering, is an inventor and entrepreneur who works at the intersection of biology and artificial intelligence, a specialization that makes him a world-renowned leader in generative biology.

Further reading:

• How generative biology can wipe out our most devastating diseases — for good
• How technology is tackling questions that confound modern medicine
• How we can deliver a better tomorrow through generative biology
• The frontiers of generative biology | MaRS Impact Health 2024

Subscribe to Solve for X: Innovations to Change the World here. And below, find a transcript to “Cracking the code: How generative biology could transform medicine.” This interview was recorded at MaRS Impact Health in June 2024.

Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.