Professor Michael Crawford is a renowned scientist and Director of the Institue of Brain Chemistry and Human Nutrition in Imperial College London. He’s known for his research demonstrating the essential role of omega-3s specifically DHA in brain development and human evolution. He’s been pioneering this research since the 70s and he’s 95 years old himself.

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Timestamps:

00:00 Intro

01:00 How Dr Crawford started researching DHA and omega-3s

04:00 Relationship between DHA and brain structure across species

07:00 How DHA drove the evolution of the human brain

12:20 Did humans evolve because of hunting land animals or consuming seafood

16:10 How a waxy fatty layer covering human babies makes us so different from other land animals

19:50 Bon Charge sponsorship

20:50 How the early stages of human brain evolution might have looked like

24:20 Why did DHA allow our brains to develop so well

27:20 Declining IQ and brain health conditions

31:00 Behavioral disorders and DHA

34:05 Iodine and other nutrients for brain development

36:55 Dr Crawford’s amazing cognition at the age of 95

39:20 How much DHA would people need per day

41:40 Is fish high in heavy metals

46:40 Omega-3s from meat

50:20 Plant-based omega-3s

51:20 Bottleneck for cranial capacity for land animals

54:55 Supplementing vs eating seafood

56:20 Omega-6 vs omega-3s

57:30 What needs to be done for fixing nutrition

01:03:30 Can you catch up with lost brain development

01:06:00 Are omega-3s easily oxidized

01:07:35 Advice for young researchers

01:10:05 Dr Crawford’s book

My 2026 longevity routine: https://youtu.be/OceysodInIo

100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyi

Dr. Benjamin Blue is the Chief Executive Officer of Ora Biomedical, where he leads the company’s mission to develop therapies that target the biology of aging to prevent and treat disease. Dr. Blue holds a Ph.D. in Molecular Medicine and Mechanism of Disease (M3D) from the University of Washington School of Medicine and a B.S. in Biochemistry from the University of Oregon.

Timestamps:

00:00 Intro

00:35 The Million Molecule Challenge to find the enxt longevity molecule

05:15 How many molecules has Ora Biomedical tested

06:45 Most remarkable results in life extension so far

10:45 The process of finding life extension molecules

16:05 What’s the maximum life extension seen

17:15 Join our online community

18:15 Common supplements seen to extend lifespan

21:55 Disappointing molecules for life extension

26:50 Aspects of health and longevity

30:45 Investigating radiation in space and aging

34:35 Likelihood of finding a molecule that extends lifespan by 200-300%

41:05 How does it translate to humans

48:25 Peptides effect on lifespan

52:05 Bottleneck in the longevity science

56:25 What compounds has Ben started taking himself

Dr Ben Blue Twitter: https://x.com/benblueAK

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/

My 2026 longevity routine: https://youtu.be/OceysodInIoStart rewinding your biological clock: https://www.siimland.co/course

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/

Timestamps:

00:00 Intro

00:41 Experts framework for bloodwork

03:41 What can bloodwork tell you about your health and what not

18:21 Brad’s top 3 most useful biomarkers

20:21 Matt’s top 3 most useful biomarkers

21:11 Is testosterone testing worth it on the population level

29:01 Michael’s top 3 most useful biomarkers

31:46 Matt’s most misleading biomarker

34:01 Brad’s most misleading biomarker

34:41 Biological age tests

37:22 Join my online community

38:23 ApoB

44:45 HDL cholesterol

48:50 Is low LDL associated with increased mortality

58:45 Blood sugar markers

01:02:12 How important are glucose spikes

01:12:12 How often should you take bloodtests

01:15:35 Liver markers

01:19:30 When you shouldn’t measure everything

01:22:40 Galleri cancer blood test

01:25:17 Cost of bloodworkMatt Kaeberlein PhD is a biogerontologist and professor at University of Washington: https://www.youtube.com/@UCSna7385c3Xg_4Too92NKMw

Michael Lustgarten PhD is an exercise scientist and longevity researcher: https://www.youtube.com/@UCT1UMLpZ_CrQ_8I431K0b-g

Dr Brad Stanfield is a family medicine doctor in New Zealand: https://www.youtube.com/@DrBradStanfield

My 2026 longevity routine: https://youtu.be/OceysodInIo