Season 2 EP 74 Interstitial Inflammatory Stasis: A New Lens on Chronic Pain Mechanisms

In this episode, we unpack the Interstitial Inflammatory Stasis (IIS) hypothesis introduced by Tuckey et al. (2021) in Frontiers in Pain Research. The authors propose that after injury or immune activation, inflammation can become “trapped” within the body’s microscopic fluid channels creating a self-perpetuating loop of congestion, fascial tension, and pain.

You’ll learn how this model integrates existing pain theories into one fascia-based framework. We’ll also explore how these ideas align with occupational therapy practice: restoring interstitial flow through movement, breath, manual therapy, and autonomic regulation.

Join the fascia-informed conversation: The Fascia-Informed Therapist ™ - Grounded in science. Practicing on the cutting edge.

References

Benias, P. C., Wells, R. G., Sackey-Aboagye, B., Klavan, H., Reidy, J., Buonocore, D., Miranda, M., Kornacki, S., Wayne, M., Carr-Locke, D. L., & Theise, N. D. (2018). Structure and Distribution of an Unrecognized Interstitium in Human Tissues. Scientific reports, 8(1), 4947. https://doi.org/10.1038/s41598-018-23062-6

Tuckey, B., Srbely, J., Rigney, G., Vythilingam, M., & Shah, J. (2021). Impaired Lymphatic Drainage and Interstitial Inflammatory Stasis in Chronic Musculoskeletal and Idiopathic Pain Syndromes: Exploring a Novel Mechanism. Frontiers in pain research (Lausanne, Switzerland), 2, 691740. https://doi.org/10.3389/fpain.2021.691740