In this episode of RhAPPcast, host Amanda Mixon, PA-C, leads a 2026 Fireside Chat exploring the intersection of rheumatology and gastroenterology. Joined by Kim Orleck, PA-C (GI APP), and Wendy Simmons, PA-C (Rheumatology APP), the panel discusses the shared inflammatory pathways linking Crohn’s disease, ulcerative colitis, psoriatic arthritis, and ankylosing spondylitis, with a focus on the gut–joint–skin axis and the IL-23, IL-17, and TNF pathways.

The conversation highlights early screening for overlapping immune-mediated inflammatory diseases (IMIDs), recognizing subclinical gut inflammation, and selecting cross-indication therapies such as JAK inhibitors and IL-23 inhibitors based on disease severity, comorbidities, and cardiovascular risk. Listeners will gain practical insights into biomarker use (including fecal calprotectin), second-line treatment strategies after TNF failure, and the importance of real-time collaboration between rheumatology and GI providers to optimize patient outcomes.

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In this RhAPPcast episode, host Amanda Mixon, PA-C, is joined by Wendy Simmons, PA-C, to discuss the role of guselkumab in inhibiting structural damage in psoriatic arthritis. The conversation explores clinical trial data, real-world experience, and the importance of preventing radiographic progression to preserve long-term joint function. This episode highlights how IL-23 inhibition fits into a domain-based treatment approach, including considerations for skin disease, comorbidities, and overlapping conditions such as inflammatory bowel disease.

In this FAQ video, Iris Zink, MSN, ANP-BC, RN-BC, shares practical strategies for discussing weight management with patients living with psoriatic arthritis. She outlines how obesity drives systemic inflammation, increases disease activity, and raises cardiovascular risk, and explains why addressing BMI should be part of routine rheumatology care. This episode explores patient-centered communication techniques, the role of anti-inflammatory nutrition and whole-food approaches, and how to incorporate conversations about GLP-1 medications, diabetes screening, and cardiovascular risk reduction into everyday practice. Designed for rheumatology clinicians and advanced practice providers, this video offers real-world tips to improve outcomes in psoriatic arthritis through compassionate, proactive weight management discussions.