A transplant saves a life… but can also make the body attack itself. That's what Graft Versus Host Disease (GVHD) does, and why nurses need to catch it early. You may have never seen it before, but this episode will tell you what it looks like at the bedside and the early clues you can’t afford to miss.

Through a real patient case, Anthony, RN explains why GVHD is easy to overlook, how to think through common differentials, and what matters most when it comes to helping patients stabilize and recover.

Topics discussed in this episode:

1. CCOT's rapid response model
2. The patient’s condition weeks after allogenic transplant
3. Anthony's assessment and what raised red flags
4. Why early symptoms can get misread or minimized
5. How Graft Versus Host Disease develops
6. Why emotional support is crucial to recovery
7. Acute vs. chronic Graft Versus Host Disease
8. Important early clues of Graft Versus Host Disease
9. Priority interventions for Graft Versus Host Disease
10. How Anthony’s app can help bedside nurses

You can connect with Anthony or learn more about his apps here:

https://thehumblenurse.com/

Mentioned in this episode:

CONNECT 📸 Connect on Instagram: https://www.instagram.com/therapidresponsern/ 📚 Check out my course: https://www.rapidresponseandrescue.com/learnmore 🧑‍💻Check out my website: https://www.rapidresponseandrescue.com/ 📬 Subscribe to my newsletter: https://www.rapidresponseandrescue.com/login 🎁 Affiliation and discounts: https://www.rapidresponseandrescue.com/therapidresponsern ✅ Earn CE’s for listening to podcasts through RNegade: https://rnegade.thinkific.com/?ref=d9d541 SAY THANKS 💜Leave a review on Apple Podcasts: https://podcasts.apple.com/ca/podcast/rapid-response-rn/id1535997752 💚Leave a rating on Spotify: https://open.spotify.com/show/55LQqeDg6XFeixvZLEp4xE ⏱️ To get the FREE Rapid Response RN Assessment Guide and the coupon code for $10 off the cost of the course, message Sarah on Instagram @TheRapidResponseRN and type the word PODCAST! This episode was produced by Podcast Boutique https://www.podcastboutique.com

Rapid Response Academy Winter 2026 Cohort

https://www.rapidresponseandrescue.com/rra

You know those moments when something just “feels off?” That’s when you should trust your instincts and speak up because timing can completely change a patient’s outcome.

In this episode, Sarah is joined by Dr. Oscar Mitchell, Associate Director of the Center for Resuscitation Science and Director of the Medical Rapid Response Team at the Hospital of the University of Pennsylvania. They break down one septic shock case across two timelines: first, when rapid response is called early and there's still time to intervene, and later, when the patient is already crashing.

You’ll hear what a calm, collaborative rapid response call looks like, which signs of deterioration should never be ignored, and how to effectively share your concerns with a provider. This episode is for anyone who might call a rapid response AND for those who respond to emergencies.

Topics discussed in this episode:

1. Introduction to the patient and the 5PM timeline
2. What the ideal provider–nurse collaboration looks like
3. Early signs of deterioration that were missed
4. Why some nurses hesitate to call rapid response
5. The patient’s vitals at 10AM and why rapid response was called
6. Why the documented respiratory rate might not be reliable
7. Why blood pressure can be misleading
8. SBAR and CUS frameworks for escalation
9. Dr. Mitchell’s research on delays in RRT activation and mortality
10. Early warning signs you should never ignore

Register for the REVIVE Conference and use code RAPID50 to get $50 off!

https://www.revive-conference.com/

Check out Dr. Mitchell's research here:https://pubmed.ncbi.nlm.nih.gov/36349290/

Mentioned in this episode:

Rapid Response Academy Winter 2026 Cohort

https://www.rapidresponseandrescue.com/rra

The science is finally catching up to what clinicians have long known: more fluids aren't always the answer to septic shock. In this episode, host Sarah Lorenzini and Jaclyn Bond MSN-LM, MBA-HM explain what the ANDROMEDA-SHOCK 2 trial reveals about physiology-guided sepsis resuscitation and why fixed-volume fluid strategies can lead to avoidable harm.

They break down how dynamic fluid responsiveness testing helps teams stop guessing, and how tools like FloPatch support real-time assessment of carotid flow time and stroke volume. You'll leave with a clearer idea of when to give fluids, when to stop, and how to justify the decision.

Topics discussed in this episode:

1. The purpose and key findings of the ANDROMEDA-SHOCK 2 study
2. Why dynamic measures of fluid responsiveness matter more than static vitals
3. What recent meta-analysis data shows about physiology-guided fluid strategies
4. Carotid flow time: what it is, how it’s measured, and how it guides decisions
5. Hemodynamic assessment and bedside limitations
6. How FloPatch supports real-time assessment so you can make individualized fluid decisions
7. SEP-1 2026 guideline updates and why it’s better for patients
8. How to apply these principles to your workflow

Website: www.flosonicsmedical.com

See FloPatch in action: https://hubs.ly/Q03-68Hg0

Mentioned in this episode:

Rapid Response Academy Winter 2026 Cohort

https://www.rapidresponseandrescue.com/rra