Protein folding

This episode is about protein folding, specifically the protein folding problem that has pervaded biochemistry since 1960, when the first atomic-resolution protein structure was presented. First I will explain what proteins are, why they are important, what they are made of - proteins 101 - then begin unravelling the problem of how they fold. We will explore the motivations behind the problem and its greatest challenges. Finally we’ll consider the existing methods for determining protein structure, with particular focus on DeepMind’s AlphaFold, before finishing with the future of protein folding.

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