Measles cases are rising world-wide so now's the time to brush up on this previously rare life threatening and vaccine preventable illness.

This episode was written by pediatricians Tammy Yau and Lidia Park with content support from Ritu Cheema (pediatric infectious disease). Pediatricians Tammy and Lidia take full responsibility for any errors or misinformation.

Follow us on Twitter/X @Pediagogypod, Instagram/Threads @pediagogy, Bluesky @pediagogypodcast.bluesky.social, and connect with us at pediagogypod@gmail.com

Key Points:

• Measles is a highly contagious vaccine preventable viral infection. From 1 single person infected with measles, an average of 18 people can be infected compared to an average of 10 for Ebola and an average of 6 for COVID.
• 2 doses of the live attenuated measles vaccine is 97% effective at preventing measles infection
• Herd immunity prevents wide-spread measles outbreaks. The threshold needed to prevent large scale measles outbreaks is 95%. Only 92.7% of kindergarteners in the US received both MMR shots for the 2023-2024.
• Symptoms of measles includes cough, conjunctivitis, coryza (rhinorrhea), Koplik spots (white spots in the mouth), and rash spreading from the face down, Serious complications include death (1-3 deaths per 1000 cases), encephalitis (20% mortality), and subacute sclerosing panencephalitis (SSPE) which is almost universally fatal.

Sources:

• “What’s Old is New Again: Measles”. Pediatrics (2025) 155 (6): e2025071332.
• https://doi.org/10.1542/peds.2025-071332
• “CDC Confirms Worst Year for Measles since 1992”. AAP News. Sean Stangland. Jul 9 2025.
• “Vaccines Matter: Measles and Its Complications”. Pediatrics (2025) 156 (1): e2025071622. https://doi.org/10.1542/peds.2025-071622
• Mina MJ, Metcalf CJE, de Swart RL, Osterhaus ADME, Grenfell BT. Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality. Science. 2015;348(6235):694–699. PubMed doi: 10.1126/science.aaa3662
• Mina MJ, Kula T, Leng Y, et al. Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens. Science. 2019;366(6465):599–606. PubMed doi: 10.1126/science.aay6485
• Lin WH, Kouyos RD, Adams RJ, Grenfell BT, Griffin DE. Prolonged persistence of measles virus RNA is characteristic of primary infection dynamics. Proc Natl Acad Sci U S A. 2012;109(37):14989-14994. doi:10.1073/pnas.1211138109
• AAP Red Book: Measles
• Medical vs Nonmedical Immunization Exemptions for Child Care and School Attendance: Policy Statement. Pediatrics (2025) 156 (2): e2025072714. https://doi.org/10.1542/peds.2025-072714

Ever wonder what if the cafe au lait macule on your patient might be something more than just a benign birth mark? Learn more about neurofibromatosis 1 and other genetic disorders associated with cafe au lait macules in today’s episode.

This episode was written by pediatricians Tammy Yau and Lidia Park with content support from Suma Shankar (pediatric genomic medicine). Pediatricians Tammy and Lidia take full responsibility for any errors or misinformation.

Follow us on Twitter/X @Pediagogypod, Instagram/Threads @pediagogy, Bluesky @pediagogypodcast.bluesky.social, and connect with us at pediagogypod@gmail.com

Key Points:

• Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with complete penetrance but variable expression.
• NF1 can be diagnosed clinically if a patient has the following features and meets the specific clinical criteria: cafe au lait macules, neurofibromas, freckling, optic gliomas, iris hamartomas, an osseous lesion, and/or a first degree relative with NF1

Sources:

Pediatrics, Miller et al (2019) 143 (5): e20190660. https://doi.org/10.1542/peds.2019-0660

Have you ever wondered if your patient pausing to breathe in their sleep is concerning or not? Learn about the signs of central sleep apnea and which medical conditions it is often associated with in pediatric patients in this episode.

This episode was written by pediatricians Tammy Yau, Lidia Park, and Jessica Ahn, with content support from Ambika Chidambaram (UCD pediatric pulmonology). Pediatricians Tammy and Lidia take full responsibility for any errors or misinformation.

Follow us on Twitter/X @Pediagogypod, Instagram/Threads @pediagogy, Bluesky @pediagogypodcast.bluesky.social, and connect with us at pediagogypod@gmail.com

Key Points

• Central sleep apnea (CSA) occurs when the brain’s central respiratory drive can’t send proper signals to the muscles that are part of breathing.
• CSA is diagnosed by a polysomnogram if there are apneic episodes that last 20 seconds or longer or if they are associated with oxygen desaturations, arousals, or heart rate changes (specific criteria in footnote).
• Central apneas are considered normal during certain stages of sleep (onset, during REM, after arousal), in premature infants less than 37 weeks corrected gestational age, and when ascending to altitudes greater than 3500 m above sea level.
• Common pediatric conditions associated with CSA include congenital central hypoventilation syndrome, achondroplasia, and Arnold-Chiari malformations.

Diagnostic Criteria for CSA

• Apneic episodes last 20 seconds or longer OR
• The apnea lasts at least the duration of two breaths during baseline breathing and is associated with an arousal or at least a 3% oxygen desaturation OR
• If the event occurs in an infant younger than 1 years old, it has to last at least the duration of two breaths during baseline breathing AND be associated with a decrease in heart rate to less than 50 beats per minute for at least 5 seconds OR less than 60 beats per minute for 15 seconds

Diagnostic Criteria for Periodic Breathing

• At least three episodes of central pauses lasting for at least 3 seconds interspersed by less than 20 seconds of normal breathing.

References

• Gipson K, Lu M, Kinane TB. Sleep-Disordered breathing in children. Pediatrics in Review. 2019;40(1):3-13. doi:10.1542/pir.2018-0142
• McLaren AT, Bin-Hasan S, Narang I. Diagnosis, management and pathophysiology of central sleep apnea in children. Paediatric Respiratory Reviews. 2018;30:49-57. doi:10.1016/j.prrv.2018.07.005
• Berry RB, Budhiraja R, Gottlieb DJ, et al. Rules for scoring respiratory events in sleep: Update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Journal of Clinical Sleep Medicine. 2012;08(05):597-619. doi:10.5664/jcsm.2172
• Javaheri S, Dempsey JA. Central sleep apnea. Comprehensive Physiology. Published online December 10, 2012:141-163. doi:10.1002/cphy.c110057
• Selim BJ, Somers V, Caples SM. Central sleep apnea, hypoventilation syndrome, and sleep in high altitude. In: Springer eBooks. ; 2017:597-618. doi:10.1007/978-1-4939-6578-6_33
• Fauroux B, AlSayed M, Ben-Omran T, et al. Management of sleep-disordered breathing in achondroplasia: guiding principles of the European Achondroplasia Forum. Orphanet Journal of Rare Diseases. 2025;20(1). doi:10.1186/s13023-025-03717-0