Oprah Winfrey Opens Up About GLP-1 Medications for Weight Loss and Calls Them Lifetime Commitment

Oprah Winfrey has been candid this week about her experiences with GLP-1 medications like Ozempic for weight loss. According to RadarOnline on January 16, she dropped about 50 pounds two and a half years ago after starting the drug but gained back 20 pounds when she stopped taking it after six months. She shared on The View and her podcast that she once blamed herself for her weight, feeling shame from constant food noise in her head, but now views obesity as a disease beyond personal control, much like addiction. Oprah explained that thin people simply do not think about food constantly, and the medication silenced that urge for her, even reducing her desire for alcohol like tequila.

RadarOnline reports Oprah calling it a lifetime commitment, similar to blood pressure medicine, as stopping leads to regain despite diet and exercise. She told CBS News she is now down to 155 pounds from a default of 211, feeling in the best shape of her life at 71 through the drugs combined with daily hiking and resistance training. Oklahoma Magazine notes she has no shame in using GLP-1s, covers costs for friends, and stresses overeating does not cause obesity but the reverse, freeing her from self-blame.

Experts echo this. Michigan State University Today featured physiologist Gina Leinninger this week, who calls GLP-1 drugs like Ozempic and Wegovy game-changers for obesity, mimicking hormones to curb hunger since the brain defends higher weights. She warns they are forever drugs, with effects reversing quickly upon stopping, and urges reserving them for those who need them amid shortages and high costs up to one thousand dollars monthly. Stony Brook Medicine on January 15 detailed how these injections or pills delay stomach emptying, leading to 15 percent average weight loss with semaglutide when paired with lifestyle changes, though side effects like nausea can be managed by eating smaller protein-rich meals slowly.

A Los Angeles Times analysis on January 15 highlighted broader impacts, noting widespread use could save U.S. airlines over five hundred million dollars yearly in fuel from lighter passengers. Business Insider affirmed Oprah's influence persists, validating medical over willpower approaches.

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