Ninja Nerds,
Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Lung Cancer, a leading cause of cancer-related mortality worldwide. We explore the pathophysiology, risk factors, and key differences between non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) to help you master this complex topic.

Our discussion covers the clinical presentation of lung cancer, including subtle early symptoms like cough, hemoptysis, and chest pain, as well as advanced findings such as pleural effusions, superior vena cava syndrome, and paraneoplastic syndromes.

Finally, we break down treatment strategies based on staging and tumor type, covering surgical interventions, chemotherapy regimens, immunotherapy, and targeted therapies such as EGFR and ALK inhibitors. We also review the latest advancements in precision medicine and the evolving role of molecular markers in guiding therapy.

Whether you’re preparing for exams or rotations or seeking a deeper understanding of lung cancer, this episode is packed with high-yield insights to boost your clinical knowledge and critical thinking.

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Ninja Nerds,
Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Myelodysplastic Syndrome (MDS), a group of hematologic disorders characterized by ineffective hematopoiesis and a risk of progression to acute myeloid leukemia (AML). We also discuss the pathophysiology of MDS, highlighting the clonal stem cell mutations that lead to dysplastic bone marrow changes and peripheral blood cytopenias.

Our discussion explores the clinical presentation of MDS, from common findings like fatigue, pallor, and bleeding tendencies to more concerning signs such as transfusion dependence and infection risk. We also cover the diagnostic approach, emphasizing the importance of bone marrow biopsy findings such as dysplastic cell morphology, ring sideroblasts, and blast percentages. Key scoring systems like the Revised International Prognostic Scoring System (IPSS-R) are discussed to guide risk stratification and treatment decisions.

In this episode, we break down treatment strategies for both low-risk and high-risk MDS, including supportive care with transfusions and growth factors, the role of hypomethylating agents like azacitidine and decitabine, and advanced interventions such as allogeneic stem cell transplantation.

Whether you’re preparing for exams, clinical rotations, or looking to expand your knowledge of hematology, this episode is packed with high-yield insights to help you understand this challenging topic.

Enjoy the episode and support us below! 🔬🩸

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Ninja Nerds,

Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Breast Cancer's pathogenesis, risk factors, and the latest advancements in screening, diagnosis, and treatment. We break down the molecular subtypes of breast cancer, including hormone receptor-positive, HER2-positive, and triple-negative disease, and discuss their clinical implications and targeted therapies.

Our discussion covers essential diagnostic tools, such as mammography, breast ultrasound, MRI, and core needle biopsy, emphasizing how to interpret imaging findings and pathology reports. We also analyze prognostic factors, including TNM staging, to guide medical therapies.

Additionally, we explore cutting-edge treatment strategies, including endocrine therapy, HER2-targeted monoclonal antibodies (e.g., trastuzumab), chemotherapy regimens, and advancements in immunotherapy for triple-negative disease. We also discuss surgical options, radiation therapy, and complications such as lymphedema and cardiotoxicity from trastuzumab.

Whether you’re studying for boards, preparing for clinical rotations, or just passionate about oncology, this episode is packed with high-yield pearls you don’t want to miss!

Join the Millionaires in Medicine Club!

Enjoy the episode and support us below! 🎙🔥

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