Project 2025. Maybe you’ve heard whispers about it. Maybe you’ve rolled your eyes. But David A. Graham read the whole thing—and he sat down with Katie to break down why this isn’t just rhetoric – it’s a roadmap already in motion. From privatizing weather data to rewinding civil rights gains, this playbook for Trump 2.0 is more extreme—and more possible—than you might think. In this episode, Graham walks us through the wildest parts of the plan, the men behind it, and why his book The Project might just be the most important one you read this year.

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Today, approximately 10,000 rare diseases collectively affect as many as 400 million people around the world, and women leaders have long been at the forefront of bringing awareness to these diseases and driving change. Katie Couric moderates a panel that includes Tania Simoncelli of Chan Zuckerberg Initiative, whose “Rare as One” campaign gives to rare disease researchers and support groups, Tara Zier who founded the Stiff Person Syndrome Research Foundation, Susan Dando of the Smith-Kingsmore Syndrome Foundation, and Dr. Christina Miyake, a researcher studying TANGO2 deficiency disorder. This panel will explore the resilience, determination, and ingenuity required to address the unique challenges in rare disease advocacy and research. Panelists will share their experiences in breaking barriers, leading patient-centered initiatives, and building collaborations that move the needle toward treatments and cures. #SponsoredbyCZI

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Rahm Emanuel has never been short on opinions—or jobs. He’s been a senior advisor to President Clinton, Chief of Staff to President Obama, a three-term Congressman, and Mayor of Chicago. Most recently, he served as the U.S. Ambassador to Japan. Now, he’s back stateside and full of ideas. From how to get the Democratic party back on track to protecting American democracy, Rahm joins Katie for a candid conversation—and may be the very first politician ever to honestly answer the question: are you running for president?

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