Research suggests that ancient viral-DNA embedded in the human genome is playing a key role in early embryo development. Around 8% of our genome consists of endogenous retrovirus DNA — the remnants of ancient infections, but knowledge of their activity is limited. Now, a team show that these sequences are required for the correct development of lab-derived embryo analogues, and for the switching on of human-specific genes.

Research Article: Fueyo et al.

News and Views: Ancient viral DNA in the human genome shapes early development

Longer whale mothers are more likely to give birth to daughters — plus, how the stink of the corpse flower waxes and wanes to attract pollinators.

Research Highlight: Big mother whales have more daughters than sons

Research Highlight: Corpse flowers waft out stinky compounds as fast as landfills do

Researchers have developed a way to use heat to recharge DNA-based computer circuits, which could help overcome one of the stumbling blocks preventing this technology from being scaled up. Although DNA strands have been used to perform computational tasks for some time, current methods can run out of energy or build up waste products, preventing their continued use. Now, using just heat a team have demonstrated a reuseable neural network based on DNA. They hope that ultimately this could be a step in the development of bigger and more powerful DNA computers that could be used to power targeted clinical therapies.

Research Article: Song & Qian

A one-time gene therapy for Huntington’s disease show promise at slowing the brain disorder’s progression — plus, how mitochondria throw out ‘tainted’ DNA.

Nature: Huntington’s disease treated for first time using gene therapy

Nature: Mitochondria expel tainted DNA — spurring age-related inflammation

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In April, Robert F. Kennedy Jr held a press conference about rising diagnoses of autism, and said he would soon be announcing a study to find the responsible agent. Although Kennedy said that environmental factors are the main cause of autism, research has shown that genetics plays a bigger part. Also, the rise in prevalence, many researchers say, is

predominantly caused by an increase in diagnoses rather than a true rise in the underlying symptoms and traits.

Although the US National Institutes of Health (NIH) announced a US$50 million to fund studies on the causes of autism, many researchers were dismayed that these developments seemed to ignore decades of work on the well-documented rise in diagnoses and on causes of the developmental condition.

This is an audio version of our Feature: Autism is on the rise — what’s really behind the increase?

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Researchers have identified a key protein that helps tick-borne encephalitis virus enter the brain. In rare cases an infection can lead to serious neurological symptoms, but little was known about how the virus interacts with human cells. Now, a team show that a protein found on the outside of cells plays an important role in infection. In mouse experiments, they show that blocking the ability of the virus to bind to this protein protected the mice from disease. Currently no treatments exist, but the team hopes that this research will ultimately lead to a viable drug for this disease.

Research Article: Mittler et al.

The squirming robot that speeds up the insertion of an emergency breathing tube — plus, the 10,000-year-old remains that could be the oldest intentionally preserved mummies

Research Highlight: Soft robot steers itself down the human airway

Research Highlight: Smoke-dried mummies pre-date Egypt’s embalmed bodies

To assess the potential impact of cuts to funding by the Trump administration, Nature trained a machine-learning bot to try and reproduce the NIH’s method of cancelling grants and applied it to science that was successfully funded around ten years ago. This thought experiment shows that highly impactful science and medical research might have been at risk had a similar process been followed a decade ago, revealing the potentially broad-reaching consequences of these actions today.

Nature Index: What research might be lost after the NIH’s cuts? Nature trained a bot to find out

News: Are the Trump team’s actions affecting your research? How to contact Nature

What researchers understand about chatbot-induced psychosis, and the AI designed viruses capable of killing E. coli bacteria.

Nature: Can AI chatbots trigger psychosis? What the science says

Nature: World’s first AI-designed viruses a step towards AI-generated life

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