Myelofibrosis and Systemic Mastocytosis — Proceedings from a Symposium Series Preceding the 67th ASH Annual Meeting and Exposition

Featuring perspectives from Prof Claire Harrison, Dr Andrew T Kuykendall, Dr Stephen T Oh, Dr Jeanne Palmer and Dr Raajit K Rampal, including the following topics:

• Introduction (0:00)
• Current Clinical Decision-Making for Myelofibrosis (MF) in the Absence of Severe Cytopenias — Dr Palmer (1:46)
• Case: A woman in her mid 70s presents with symptomatic JAK2 V61F-mutant primary MF with mild anemia and normal platelet count — John Mascarenhas, MD (16:09)
• Discussion: Asymptomatic MF; re-reads of pathology reports; "triple-negative" MF; secondary causes — Laura C Michaelis, MD (22:47)
• Discussion: Ruxolitinib-associated dermatologic cancers and weight gain — Prithviraj Bose, MD (27:34)
• Managing MF in Patients with Anemia — Dr Oh (30:21)
• Case: A man in his early 70s with splenomegaly and mild fatigue is diagnosed with JAK2 V617F-mutant primary MF and receives momelotinib — Dr Michaelis (42:34)
• Discussion: Post-hoc analysis from the SIMPLIFY-1 trial — Dr Bose (46:20)
• Managing MF in Patients with Thrombocytopenia — Dr Rampal (49:57)
• Discussion: MF with moderate thrombocytopenia — Dr Michaelis
  Case: A man in his mid 60s with primary MF and anemia, thrombocytopenia and splenomegaly has a low JAK2 V617F allele frequency — Dr Mascarenhas (1:05:46)
• Promising Novel Agents Under Investigation for MF — Prof Harrison (1:11:21)
• Case: A woman in her late 70s with primary MF with CALR1 and SF3B1 mutations and anemia receives luspatercept — Dr Michaelis
  Discussion: Luspatercept for MF-associated anemia — Dr Bose (1:24:52)
• Discussion: Promising novel therapies — Dr Mascarenhas (1:28:24)
• Current and Future Management of Systemic Mastocytosis — Dr Kuykendall (1:32:40)
• Discussion: Initial assessment of patients diagnosed with systemic mastocytosis; avapritinib dosing — Dr Bose (1:49:12)
• Discussion: Systemic mastocytosis with associated hematologic neoplasm — Dr Bose (1:52:24)
• Discussion: Bezuclastinib for systemic mastocytosis — Dr Bose (1:55:23)

CME information and select publications