Managing Opioid Overdose: Signs, Symptoms, and Reversal Agents

Opioid overdoses remain a leading cause of preventable death - and pharmacy teams are on the front lines of response.

In this episode, TRC Healthcare Associate Editor and Clinical Pharmacist Don Weinberger, PharmD, PMSP, discusses how to recognize opioid overdose, compares naloxone and nalmefene options including the new nalmefene auto-injector, and shares tips for counseling patients and caregivers on using opioid reversal agents effectively.

This is an excerpt from our December 2025 Pharmacy Essential Updates continuing education webinar series.

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CE Information:

TRC Healthcare offers CE credit for this podcast for pharmacist subscribers at our platinum level or higher and pharmacy technician subscribers. Log in to your Pharmacist’s Letter or Pharmacy Technician’s Letter account and look for the title of this podcast in the list of available CE courses. None of the speakers have anything to disclose.

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Clinical Resources from Pharmacist’s Letter, Pharmacy Technician’s Letter, and Prescriber Insights:

• Article: Boost Access to Naloxone or Nalmefene
• FAQ: Meds for Opioid Overdose
• Toolbox: Appropriate Opioid Use
• Chart: Opioid Reversal Agents Quick Start Guide
• FAQ: Management of Opioid Use Disorder

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