Actresses Christina Applegate and Jamie-Lynn Sigler join Kelly to share their hall passes, growing up on camera on their shows Married With Children and Sopranos, respectively, and what it was like for Christina to be diagnosed with MS while filming Dead to Me. The actresses reflect on being bred to be “good girls," how their diagnosis affects their parenting and how they maintain hope. Christina and Jamie-Lynn dish on their Bravo obsessions, which actress’s name they use as a verb, and all about their podcast MeSsy.

Dr. Emily Morse of SEX WITH EMILY joins Kelly LIVE to take all of your pressing sex questions. Dr. Emily answers your calls about foreplay, communication, lubrication, and exploration. She advises on how open relationships work, how to get the spark back, and all those alphabet spots in the body! Plus you won’t want to miss a famous couple (Jerry O’Connell and Rebecca Romijn) call in to get some advice about their sex life!

The booking to end all bookings, Queen of EVERYTHING, Oprah graces the podcast with her presence and wisdom. After 25 years, Oprah shares the moment she knew it was time to step away from her show, and gives Kelly some career advice. She tells Kelly about the love of her life, if she ever has FOMO, coping with losing a dog, and what she really thought about her bestie Gayle King going to space. Kelly finally gets to ask Oprah if she would have liked her hostess gift...and spoiler she would REGIFT! PLUS, Oprah tells a never before shared story about her royally famous neighbors, The Sussexes (aka Harry and Meghan). And you don't want to miss hearing what Oprah's currently obsessed with and why she decided to do her new podcast, The Oprah Podcast!