In this age of algorithms, how do we ensure clinical care is both science based and personalized? In this interview, Dr. Ryan Metcalf, section chief of Transfusion Medicine at ARUP Laboratories and University of Utah Health and associate professor of Pathology at the University of Utah School of Medicine, shares the story behind the new platelet transfusion guideline from the Association for the Advancement of Blood and Biotherapies (AABB). He describes how the authors addressed patient-specific variation and the inherent uncertainty of scientific evidence.

Related Information:

• Platelet Transfusion: 2025 AABB and ICTMG International Clinical Practice Guidelines [https://arup.utah.edu/education/metcalf-platelet-2025.php/]
• JAMA® Article: Platelet Transfusion: 2025 AABB and ICTMG International Clinical Practice Guidelines [https://jamanetwork.com/journals/jama/fullarticle/2834703]
• JAMA® Clinical Reviews Podcast: Platelet Transfusion: Best Practice Guidelines [https://edhub.ama-assn.org/jn-learning/audio-player/18977738]

Health equity and personalized medicine share a common goal: tailoring care to the needs of each individual. In this interview, Dr. Octavia Peck Palmer from the University of Pittsburgh Medical Center, immediate past president of ADLM, explains how diversity is foundational to advancing clinical science and improving patient outcomes.

After nearly dying from a mysterious disease during medical school, Dr. David Fajgenbaum dedicated his career to breaking down barriers in biomedical research. Fajgenbaum is now an associate professor of medicine at the University of Pennsylvania and cofounder of Every Cure. In this conversation, we discuss his personal diagnostic journey and the errors and delays he encountered along the way. We also explore why academic medicine needs to go beyond generating disparate pieces of scientific knowledge and instead turn that information into nodes on a network that spans specialty silos to speed the discovery of effective treatments.