• Key considerations when preparing patients with ALL for CAR T-cell therapy

  • Jul 12 2024
  • Duración: 26 m
  • Podcast

Key considerations when preparing patients with ALL for CAR T-cell therapy

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  • Resumen

  • During the ALL Hub Steering Committee meeting, André Baruchel chaired a discussion on “What are the key considerations when preparing patients with ALL for CAR T-cell therapy ?”, featuring Andrea Biondi, Anita Rijneveld, and José María Ribera.


    The discussion topics included:

    • Key considerations when selecting patients: stable disease, degree of antigen expression, burden of bone marrow disease, and number of circulating tumor blasts
    • Bridging therapy and lymphodepletion considerations
    • The impact of prior exposure to blinatumomab and inotuzumab on CAR T-cell outcomes
    • Indications for the use of tisagenlecleucel in pediatric ALL
    • Indications for the use of brexucabtagene autoleucel in adult ALL

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