JNP Podcasts: Hypercapnia elicits changes in diaphragm neuromotor control

In this episode, coauthor Obaid U. Khurram discusses their recently published research, "Hypercapnia Impacts Neural Drive and Timing of Diaphragm Neuromotor Control." The study explores the complex neuromotor control of the diaphragm muscle (DIAm) under hypercapnic conditions, an area that has not been fully understood. Dr. Khurram explains how hypercapnia increases motor unit recruitment and discharge rates, indicating an enhanced respiratory drive. The research also reveals how hypercapnia affects the postinspiratory (descending) ramp of diaphragm EMG activity, shortening it to facilitate faster respiratory rates. Tune in for valuable insights into the physiological mechanisms of diaphragm function and adaptation in response to elevated carbon dioxide levels.

Hypercapnia impacts neural drive and timing of diaphragm neuromotor control Obaid U. Khurram, Maximilian J. Kantor-Gerber, Carlos B. Mantilla, and Gary C. Sieck

Journal of Neurophysiology 2024 132:6, 1966-1976