Andrew speaks with Dr. Michael Osterholm, founding director of the Center for Infectious Disease Research and Policy Center at the University of Minnesota about his new book, "The Big One: How We Must Prepare for Future Deadly Pandemics", which is an urgent warning about the next global health crisis. Dr. Osterholm explains why the continued focus on COVID's origin is distracting from the critical lessons we need to learn. He also offers a frank critique of "meaningless" plexiglass shields and six-foot distancing, sharing what truly works in transmission prevention. And, he outlines why these biological threats are a core national security challenge for U.S. military forces that demands an increase in research and funding.

Michael speaks with Zack Cooper, a senior fellow at the American Enterprise Institute, about the evolving dynamics of US policy toward China and the Indo-Pacific. Zack discusses how President Trump's pursuit of a meeting with Xi Jinping has shaped US policy and offers new analysis on the timeline for a potential Chinese invasion of Taiwan. Zack also confronts the reality of the so-called "axis of upheaval"—a tightening cooperation between China, Russia, North Korea, and Iran—and what it means for US foreign policy.

Michael speaks with President and Founder of the Institute for Science and International Security David Albright about the state of the Iranian nuclear program following US and Israeli strikes. David, a renowned expert on Iran's nuclear program, provides updated analysis on the systematic destruction of key facilities and shares his insights on the challenges of reconstituting the program, the fate of missing enriched uranium, and the ongoing efforts of international monitors.

Andrew speaks with Jeffrey Feltman, former United Nations Under-Secretary-General for Political Affairs and a distinguished fellow at the Brookings Institution. Jeffrey takes us inside the precarious state of post-civil war Syria, the deep-seated sectarian and geopolitical tensions that fueled the conflict, and the complex roles of the US and regional powers who want a stake. He also shares his insights on the ongoing threat from insurgent groups and the challenges of establishing a stable, unified government.

After a summer of action in the Arctic, Andrew Shapiro re-visits his conversation with former Pentagon Arctic policy head Iris Ferguson about this strategic frontier. Iris explains how melting sea ice is ushering in a new era of great power competition, ending decades of 'Arctic exceptionalism.' Iris, the DOD's first Deputy Assistant Secretary for the Arctic, discusses Russia's interests, China’s pursuit of influence as a 'near-Arctic state,' and the US imperative to bolster homeland defense, domain awareness, and alliances from Greenland to Alaska.

Michael Allen talks with Craig Singleton, China Program Senior Director and Senior Fellow at the Foundation for Defense of Democracies, about the new frontiers of the US-China tech competition. Craig explains that while trade talks are in a "tactical pause," China's dominance in rare earth minerals and its willingness to use them as leverage reveal a key US vulnerability. The conversation also explores the debate over US semiconductor export controls. He argues that selling advanced chips like Nvidia's H20 to China's military and intelligence apparatus undermines America's technological edge. Craig also explores China's market-dominating strategies in materials like polysilicon and technologies such as LIDAR and display technologies, which pose risks related to supply chain choke points and potential cyber-physical vulnerabilities.