Impulse - Meeting Healthcare Pioneers Podcast Por Mathieu Chaffard arte de portada

Impulse - Meeting Healthcare Pioneers

Impulse - Meeting Healthcare Pioneers

De: Mathieu Chaffard
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Impulse is the podcast where we dive into the most exciting breakthroughs in healthcare of our time. In each episode, we sit down with some of the brightest minds who are using technology to rethink the way we care!Mathieu Chaffard Economía Enfermedades Físicas Exito Profesional Higiene y Vida Saludable
Episodios
  • #49 - Reverse-engineering cancer survival - Nicolas Wolikow - Cure51

    #49 - Reverse-engineering cancer survival - Nicolas Wolikow - Cure51
    Oct 19 2025
    Can we learn from extreme cancer survivors to develop new treatments? This is the bet that Nicolas Wolikow and his team at Cure51 are making. Backed by the world's top cancer centers and specialists, they work around the clock to build the largest-ever health dataset of patients who defied the odds—people diagnosed with stage 4 cancer who were given a few months to live, yet survived more than five years. The goal is to understand what makes their biology unique and what characterises their incredible response to the treatments they received. A unique approach to identify new therapeutic targets and enrich our arsenal against a disease whose incidence continues to grow day by day. In this episode, Nicolas lifts the veil on the rigorous method they follow to achieve this feat, from the collection of clinical and multi-omics data to the identification of these targets and their validation in clinical trials. A method to reverse-engineer cancer survival, founded on the latest progress in computational biology, and whose success depends on the close collaboration between patients, hospitals, and industrial partners! Timeline: 00:00:00 - Nicolas’ background as an entrepreneur at the interface of healthcare, technology, and digital innovation 00:06:45 - Understanding the mechanisms behind cancer thanks to exceptional survivors 00:10:24 - Stories of patients in full remission after a stage 4 cancer diagnosis 00:12:21 - Building the platform to host the largest dataset of cancer survivors ever made 00:14:36 - Making sense of the survivors’ data to identify underlying biological mechanisms 00:19:28 - Early findings and novel therapeutic targets investigated so far 00:28:18 - The economic model behind Cure51 00:30:45 - Convincing hospitals and health systems to join Cure51’s mission What we also talked about with Nicolas: HLTH Europe Cancer stages Chemotherapy Rosalind Franklin Variant.bio We cited with Nicolas some of the past episodes of the series: #40 - Cracking biology through AI - JP Vert - Owkin As Nicolas mentioned during the episode, you can learn more about Cure51’s activities on their website, and follow their latest news on LinkedIn, Instagram, and Facebook. You can reach out to Nicolas via LinkedIn and find more details about the ROSALIND study in this abstract. To hear Camille Moses’ incredible story as a cancer survivor, we invite you to listen to her testimonial on the Project Purple podcast. ✉️ If you want to give me feedback on the episode or suggest potential guests, contact me over LinkedIn or via email! ⭐️ And if you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! 🙏 You can also support my work by doing a PayPal donation @ImpulsePodcast! 👍 Lastly, don’t forget to follow our activities on LinkedIn and our website!
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    44 m
  • [SNIPPET] - Nicolas Wolikow on understanding the mechanisms behind cancer

    [SNIPPET] - Nicolas Wolikow on understanding the mechanisms behind cancer
    Oct 19 2025
    To discover the whole episode, type "#49 - Reverse-engineering cancer survival - Nicolas Wolikow - Cure51" on your preferred streaming platform.
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    4 m
  • #48 - Driving precision medicine with real-world data - Blythe Adamson - Flatiron Health

    #48 - Driving precision medicine with real-world data - Blythe Adamson - Flatiron Health
    Sep 21 2025
    Disclaimer: Blythe and I both work for Roche; nevertheless, all opinions expressed in this episode are our own and do not necessarily represent the position of our employer. What's really behind the term "real-world data" in clinical science? And what can it actually be used for? I asked Blythe Adamson of Flatiron Health to find out the answer. It turns out real-world data is all the medical data collected in the “real world”, meaning outside of any clinical trial. In other words, it's the vast majority of medical data that exists. This includes everything from the results of blood tests, scans, and vaccinations to doctors' handwritten notes. While the idea of using it to develop new treatments seems obvious, the reality is far from simple. Because access to this data is disparate and varies from one country to another. Because the diversity of their modality renders their interpretation complex. And because until recently, we did not have the computational tools to make it work. But now, in the age of AI and mass digitalisation of healthcare, all of this is changing at lightning speed. Drawing on her expertise at the intersection of epidemiology, data science, and health policy, Blythe walks us through the immense challenges and opportunities of real-world data, and how they are poised to revolutionise the development of tomorrow's therapies. An episode to understand precision medicine and the central role of real-world evidence! Timeline: 00:00:00 - Blythe’s background at the interface of epidemiology, data science, and health policy 00:09:33 - The power of real-world data in medicine and drug development 00:17:11 - The barriers to accessing and leveraging real-world data at scale 00:20:26 - Two examples where AI can help make sense of real-world data 00:25:46 - Traditionally overlooked real-world data modalities in medicine 00:27:52 - Breaking down language barriers across real-world datasets 00:35:10 - Some predictions on the next AI-driven breakthroughs in oncology What we also talked about with Blythe: Operation Warp Speed Resilience Patient-Reported Outcome Measures (PROMs) Trusted Research Environments De-identification American Society of Clinical Oncology (ASCO) Circulating tumor DNA (ctDNA) American Heart Association European Society of Cardiology We cited with Blythe some of the past episodes of the series: #40 - Cracking biology through AI - JP Vert - Owkin As Blythe mentioned during the episode, you can visit her blog at blytheadamson.com for more information about her work. The book recommended by Blythe is Spillover: Animal Infections and the Next Human Pandemic by David Quammen. You can get in touch with Blythe via LinkedIn, and follow the activities of Flatiron Health on LinkedIn, X, and Instagram. ✉️ If you want to give me feedback on the episode or suggest potential guests, contact me over LinkedIn or via email! ⭐️ And if you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! 🙏 You can also support my work by doing a PayPal donation @ImpulsePodcast! 👍 Lastly, don’t forget to follow our activities on LinkedIn and our website!
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    43 m
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