Immunotherapy for Atherosclerosis

What role does inflammation play in atherosclerosis? In our latest episode of The Physiological Reviews Podcast, Dr. Carol Ann Remme talks with authors Dr. Esther Lutgens (Mayo Clinic) and Dr. Claudia Monaco (University of Oxford) about their recent Review on immunotherapy for atherosclerosis. The authors discuss the network of multiple immune cell types and subsets of the innate and adaptive immune system that occupy arteries. In addition, Monaco et al. discuss local inflammation in the arterial wall or plaque compared to systemic inflammation. The authors also discuss atherosclerosis as a process of aging, rather than as a disease. What is the holy grail of safe immunotherapeutic approaches and the future of personalized medicine for atherosclerosis? Listen now to learn more.

Claudia Monaco, Coleen A. McNamara, Bram Slütter, Amanda C. Foks, Stefan Bekiranov, Willem J.M. Mulder, Isabel Gonçalves, and Esther Lutgens Immunotherapy for atherosclerosis Physiological Reviews, published May 21, 2025. DOI: 10.1152/physrev.00016.2024