How NodThera’s NLRP3 Marks A New Era for Obesity Treatment

Cardio-metabolic diseases are the world’s biggest killer. But what if the next generation of treatments could change everything?

This week on Leading Beyond The Lab, Lawrence Rose sat down with Jyothis George, CMO of Nodthera, and a global thought leader in the obesity space, shaping the future of cardio-metabolic and inflammatory disease innovation. Jyothis has led global programs across GLP-1, SGLT2, PCSK9 and now the emerging NLRP3 inhibitor class. His work spans companies such as Novo Nordisk, Amgen, Boehringer Ingelheim and his move into biotech with NodThera marks a shift from big-Pharma leadership into next-wave therapeutic development.

In this episode, Jyothis covers:

- How NodThera is shaping the future of metabolic and inflammatory disease treatment.

- A look at the mindset and challenges behind leading in a high-stakes biotech environment.

- Why the right investors often play a critical mentorship role in biotech growth.

- Exploring why endocrinology remains underfunded and overlooked in biotech circles.

- How he previously worked with Eli Lilly (led by David Ricks), contributing to their efforts in the cardiometabolic space.

- Reflections on personal legacy, long-term impact, and how to get in touch.

If you’re interested in cardio-metabolic innovation, GLP-1 evolution, biotech strategy or leadership at the cutting edge of science, this episode is worth your time.

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Jyothis George

CMO at NodThera

LinkedIn: https://www.linkedin.com/in/jyothisgeorge/

Lawrence Rose

Co-Founder + Talent Solutions Director At ARTO

LinkedIn: https://www.linkedin.com/in/lawrencerose/

Timestamps:

01:40 NodThera's Role in Future Endocrinology

10:48 Leadership in Biotech

21:05 Investment and Mentorship

30:58 Endocrinology's Underinvestment

38:13 Jyothis George: Legacy & Contact

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