In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia.

Often overlooked, microglial cells are the brain's immune system and play a central role in determining whether the brain thrives or degenerates over time.

Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer's, Parkinson's, and more.

Most importantly, this episode highlights how everyday lifestyle choices — from diet and exercise to metabolic health — directly influence brain function and long-term cognitive resilience.

Join us as we delve into:

• What microglia are and why they control brain health
• The difference between M1 (destructive) and M2 (protective) states
• How metabolism shapes the brain's immune response
• Why conditions like Alzheimer's are rooted in immune dysfunction
• The connection between blood sugar, insulin, and brain degeneration

This episode is for you if:

• You want to protect your brain and prevent cognitive decline
• You're interested in the science of Alzheimer's and neurodegeneration
• You want actionable strategies to improve brain health
• You're curious about the future of brain optimization and longevity

You can also find this episode on…
Youtube: https://youtu.be/EMrlchMOZKk

Find more from Dr. David Perlmutter
Website: https://www.drperlmutter.com
Book: https://braindefenders.com
LinkedIn: https://www.linkedin.com/in/david-perlmutter-md/
Instagram: https://www.instagram.com/davidperlmutter/
Facebook: https://www.facebook.com/DavidPerlmutterMd/

Find more from Health Optimization Medicine and Practice (HOMeHOPe):
Website: https://homehope.org/
Instagram: https://www.instagram.com/homehopeorg/
Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026
Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

Find more from Troscriptions
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In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval as they explore chronobiology — and how modern life is disrupting the body's natural rhythms.

From jet lag and shift work to late-night scrolling and irregular meals, the conversation dives into what Dr. Ted calls "circadian pollution" — the mismatch between our biology and the environments we've created.

More importantly, the team breaks down simple, powerful tools to re-entrain your body clock using light, food timing, and movement — all foundational principles in Health Optimization Medicine.

Join us as we delve into:

• What chronobiological re-entrainment actually means
• The difference between the brain clock and organ clocks
• How light, food, and movement act as biological time signals
• Why late-night eating creates "metabolic jet lag"
• How modern life creates circadian disruption

This episode is for you if:

• You struggle with sleep, fatigue, or inconsistent energy
• You travel frequently or work irregular hours
• You want to optimize your circadian rhythm naturally
• You're looking for simple, zero-cost ways to improve health

You can also find this episode on…
YouTube: https://youtu.be/WcheAJNzq2k

Find more from Health Optimization Medicine and Practice (HOMeHOPe):
Website: https://homehope.org/
Instagram: https://www.instagram.com/homehopeorg/
Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026
Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

Find more from Troscriptions:
Website: https://troscriptions.com/
Instagram: https://www.instagram.com/troscriptions/
Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Jodi Duval, Dr. Allen Bookatz, and Dr. Ted Achacoso as they explore the future of clinical intelligence — and why medicine must move beyond single biomarkers to understanding networks within the body.

Rather than chasing isolated lab values like glucose, cholesterol, or testosterone, the conversation shifts toward a systems-based approach — where every biomarker is part of a dynamic network of relationships.

From metabolomics to hormone balance, this episode explains why optimizing health requires understanding how different systems interact, adapt, and influence each other in real time.

Join us as we delve into:

• Why single biomarkers are only "nodes" in a larger biological network
• The concept of nodes and edges in human physiology
• How glucose, thyroid, and metabolic systems are interconnected
• Why cholesterol, inflammation, and B vitamins must be viewed together
• The risks of optimizing one biomarker (like testosterone) in isolation

This episode is for you if:

• You've been told to "fix" a single lab value but still feel off
• You want to understand your lab results in a deeper, systems-based way
• You're a practitioner looking to move beyond reductionist medicine
• You're interested in metabolomics and the future of health optimization

You can also find this episode on…
Youtube: https://youtu.be/CMbdZEnnuGo

Find more from Health Optimization Medicine and Practice (HOMeHOPe):
Website: https://homehope.org/
Instagram: https://www.instagram.com/homehopeorg/
Virtual Symposium 2026:https://homehope.org/homehope-virtual-symposium-2026
Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://www.homehope.org/

Find more from Troscriptions:
Website: https://troscriptions.com/
Instagram: https://www.instagram.com/troscriptions/
Use POD10 to get 10% OFF your Troscriptions purchase at https://www.troscriptions.com/