Glymphatic homeostasis in heart failure- more in but not out?

Welcome to the 26th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with first author Dr Marios Kritsilis and senior author Associate Professor Iben Lundgaard of the Brain article entitled: Loss of glymphatic homeostasis in heart failure

This academic duo from Lund University discuss their fascinating findings exploring glymphatic homeostasis in a mouse model of heart failure. Counter-intuitively, there may be more influx but not efflux associated with reduced ejection fraction. This has interesting implications on heart failure associated cognitive changes and risk of developing dementia.

Check out the full article on the Brain website as part of the March 2025 issue: https://doi.org/10.1093/brain/awae411

This episode was co-hosted, edited and produced by Xin You Tai and Roberto Bellanti, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.