Exercise Wards Off Dementia

Vidcast: https://www.instagram.com/p/DVMhbjwkUaq/

Exercise protects your brain from Alzheimer’s dementia by strengthening your brain’s natural defense mechanisms. That’s the finding of a collaborative preclinical study by neuroscientists at University of California San Francisco and Duke University. The results are published in the journal Cell.

Using aging mice the equivalent of 70 human years, the researchers demonstrate that physical activity stimulates the liver to release an enzyme called GPLD1 that strengthens the blood-brain barrier. This prevents the normal pattern where this barrier normally becomes more permeable with age permitting heightened brain inflammation and deterioration in cognition.

These results are promising and, hopefully, will be duplicated in human clinical trials. In any event, regular physical activity is already known to support general cardiovascular and neurologic health and should be a part of your day..

https://www.cell.com/cell/fulltext/S0092-8674(26)00111-X?_returnURL=https://linkinghub.elsevier.com/retrieve/pii/S009286742600111X?showall=true

https://www.sciencedaily.com/releases/2026/02/260219040752.htm

#exercise #dementia #alzheimers #bloodbrainbarrier