Evolution of Virus inactivation methods in manufacture of biologics

Viral contamination is a common threat to all animal- and human-derived biopharmaceuticals. A virus is essentially an infectious agent that is capable of infecting a host cell and to copy itself. Viruses consist of nucleic acid (DNA or RNA) in a protein coat/capsid. Those with an outer lipid layer are referred to as enveloped viruses; those without one are classified as nonenveloped or naked viruses.

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