Episode 377: Methylene Blue for Mitochondria & Performance: Benefits, Dosing & Risks with Dr. Scott Sherr

In this episode of the Flex Diet Podcast, I sit down with Dr. Scott Sherr to take a deep dive into methylene blue, mitochondrial function, and where the truth lies between online hype and fear. We talk through how methylene blue acts as a redox cycler in the mitochondria, how dosing differs for mitochondrial support versus antimicrobial use, and why high doses or poorly labeled liquid droppers can cause problems. Dr. Sherr also shares how he’s used methylene blue with athletes for recovery and endurance, including timing, half-life, and practical ranges he sees most often. We cover how mitochondrial health connects to energy, mood, focus, stress physiology, and recovery, plus resources from Transcriptions and the Health Optimization Medicine and Practice (HOMe/HOPe) framework. Sponsors: TROScriptions TX: https://troscriptions.com/?rfsn=9054607.066ddde&utm_source=refersion&utm_medium=affiliate&utm_campaign=9054607.066ddde CODE: DRMIKEDaily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8 Coming up: ISSN 2026: https://www.sportsnutritionsociety.org/ Available now: Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here. Episode Chapters: 03:11 Why Methylene Blue Now04:29 Scott Cher Origin Story05:05 Health Optimization Framework07:08 Transcriptions and Safe Sourcing08:46 Natural vs Synthetic Debate11:49 How Methylene Blue Works17:42 Who Benefits Most22:13 Athletic Performance and Recovery29:41 Dosing Timing and MAOI Effects32:13 Mitochondria and Fertility32:28 Energy Anxiety and Brain Fog33:13 Depression Beyond Serotonin35:30 Stress Pathways and Cell Danger37:00 ADHD or Sympathetic Overdrive38:50 Recovery Metrics and Downregulation42:21 GABA Support and BBB Clues47:50 Building Mitochondrial Capacity First51:35 Methylene Blue Dosing Guide57:54 Where to Learn More01:00:24 Podcast Wrap and Disclaimer Flex Diet Podcasts you may enjoy: Episode 344: Metabolic Adaptations, Lactate, and Training Smarter with Dr. Phil Batterson YouTube: https://www.youtube.com/watch?v=PPZyO1nxSPAEpisode 320: Unlocking Mitochondrial Secrets with Dr. Hemal Patel YouTube: https://www.youtube.com/watch?v=lQGXtZjJtQw Connect with Dr Sherr: Instagram: https://www.instagram.com/drscottsherr/Website: https://drscottsherr.com/YouTube: https://www.youtube.com/@drscottsherr Get In Touch with Dr Mike: Instagram: DrmiketnelsonYouTube: @flexdietcertEmail: Miketnelson.com/contact-us