Episode 223: Orforglipron 101: The Next Big Thing in Obesity Medications

If you've been waiting for a GLP-1 weight loss medication that doesn't require injections, special timing, or refrigeration—this episode is for you. Learn about the groundbreaking oral pill that could hit the market as early as 2026.

For years, effective obesity medications have meant needles. But Orforglipron could change everything. In this episode, I break down the science, clinical trial results, and approval timeline for this first-of-its-kind once-daily pill that delivers GLP-1 benefits without the injection barriers.

Whether you're needle-averse, struggle with injection site reactions, or simply want more convenient options, this new medication could expand access to life-changing obesity treatment.

Episode Highlights:

• What makes Orforglipron different from Wegovy, Zepbound, and oral semaglutide

• Clinical trial results: 12.4% average weight loss over 72 weeks

• Why this oral pill doesn't require fasting or special timing like other oral GLP-1s

• The FDA accelerated review process and potential 2026 approval timeline

• Who benefits most: patients with needle phobia, injection site reactions, or seeking maintenance therapy

• What to expect regarding insurance coverage and access once approved

Connect with Dr. Alicia Shelly:

• Website | drshellymd.com

• Facebook | www.facebook.com/drshellymd

• Instagram | @drshellymd

• Linked In | www.linkedin.com/in/drshellymd

• Twitter | @drshellymd

About Dr. Alicia Shelly

Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH. Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014. In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss, where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, "Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.

Resources:

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