Ep. 10 | 2025 Longevity Updates: Quad Agonists, MOTS-C Human Data, & Senolytic Stacking

In this episode of the Longevity Game Podcast, host Michael Ward discusses cutting-edge research in longevity, focusing on new peptide therapies, weight loss medications, and the impact of testosterone replacement therapy on brain health. The conversation highlights the importance of exercise in combating aging, the potential of quad agonist drugs for weight loss, and the promising results of the mitochondrial peptide MOTC. Additionally, the episode touches on the neuroprotective effects of TRT, emphasizing the holistic approach to health and longevity.

Takeaways

-The combination of exercise and senolytics can improve aging effects.

-Quad agonist medications show promise for significant weight loss.

-MOTC peptide enhances mitochondrial function and metabolic health.

-TRT may play a crucial role in brain health as we age.

-Prioritizing protein intake is essential for muscle retention on GLP-1s.

-Exercise is vital for maintaining muscle mass and metabolic rate.

-New data supports the efficacy of MOTC in improving insulin sensitivity.

-The future of weight loss drugs is moving towards less muscle loss.

-Senolytics may be integrated into regular training programs for better health.

-Gratitude for health professionals working during holidays is important.

Chapters

00:00 Introduction to Longevity and Performance Medicine

09:26 Exploring Senolytics and Exercise

18:35 Quad Agonist Weight Loss Breakthroughs

23:56 MOTC Peptide and Its Impact on Aging

26:00 Testosterone Replacement Therapy and Brain Health

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#longevity, #health, #peptides, #weightloss, #mitochondrialhealth, #TRT, #aging, #exercise, #metabolichealth, #GLP1