Join Dr. Brendan McCarthy, Chief Medical Officer at Protea Medical Center in Tempe, Arizona, for a deep, practical breakdown of estrone—one of the most misunderstood and under-tested hormones in women’s health.

In this episode, Dr. McCarthy explains:

• Why estrone matters far more than most routine labs suggest

• How estrone relates to inflammation, insulin resistance, body fat, and chronic disease

• What your estrone actually tells you about your metabolic load

• How phase 1 and phase 2 liver detox pathways determine whether estrogen becomes helpful or harmful

• How to use food, supplements, and prescriptions appropriately based on your labs

• Red flags to watch for with boutique labs, overpriced clinics, and “hormone hacks”

You’ll learn exactly how clinicians should evaluate estrone, how to interpret the estrone–estradiol ratio, and how to identify where estrogen metabolism is blocked so you can take meaningful steps toward better health.

If you find this helpful, please subscribe and share it with someone who wants real, evidence-based hormone education.

Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he’s helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He’s also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you’re ready to take your health seriously, this podcast is a great place to start.

👇 Tap Subscribe to learn more about what’s actually happening in your body, and what to do about it.

📘 Read Dr. McCarthy’s Book: Jump Off the Mood Swing – A Sane Woman’s Guide to Her Crazy Hormones https://www.amazon.com/Jump-Off-Mood-Swing-Hormones/dp/0999649604

📲 Follow Dr. McCarthy:

Instagram: @drbrendanmccarthy

TikTok: @drbrendanmccarthy

Website: www.protealife.com

💬 Got a question or topic for a future episode? Let us know in the comments!

In this episode, Dr. Brendan McCarthy, Chief Medical Officer at Protea Medical Center in Tempe, Arizona, takes you deep into the science of Estrone metabolism, why it becomes dominant during perimenopause and menopause, and the exact lab tests that uncover real root causes of symptoms like weight gain, mood swings, breast tenderness, irritability, fatigue, and sleep disruption.

This is Part 4 of our Estrone Series — and today’s focus is the real, science-based pathways behind estrone dominance:

• Estrone : Estradiol ratios

• 2-, 4-, and 16-hydroxyestrone pathways

• COMT function and methylation

• Liver health and detoxification capacity

• The nutrients and lifestyle factors that shift estrogen metabolism

• How to interpret patterns your regular doctor may overlook

If you’ve ever been dismissed, told your symptoms are “normal,” or felt like something is wrong that no one is addressing — this episode gives you the tools, the labs, and the language to advocate for your health.

Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he’s helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He’s also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you’re ready to take your health seriously, this podcast is a great place to start.

👇 Tap Subscribe to learn more about what’s actually happening in your body, and what to do about it.

📘 Read Dr. McCarthy’s Book: Jump Off the Mood Swing – A Sane Woman’s Guide to Her Crazy Hormones https://www.amazon.com/Jump-Off-Mood-Swing-Hormones/dp/0999649604

📲 Follow Dr. McCarthy:

Instagram: @drbrendanmccarthy

TikTok: @drbrendanmccarthy

Website: www.protealife.com

💬 Got a question or topic for a future episode? Let us know in the comments!

In Part 3 of the Forgotten Estrogen series, Dr. Brendan McCarthy—Chief Medical Officer of Protea Medical Center in Tempe, Arizona—dives deep into the misunderstood relationship between estrone and cancer.

For decades, women have been told to fear estrogen. But is estrogen really the enemy—or is it the environment within the body that determines risk?

Dr. McCarthy explains:

• How estrone functions after menopause

• Why estrogen became wrongly vilified after the 2002 Nurse’s Health Study

• The truth about inflammation, insulin resistance, and detox pathways

• The role of methylation, glutathione, and liver detox in estrogen metabolism

• What lab markers actually matter (and how to interpret them)

• Practical ways to support your hormones through nutrition, sleep, and lifestyle

This episode is about empowerment through knowledge, not fear. If you’ve ever been confused or afraid of estrogen, this conversation will change how you understand your body and your hormones.

Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he’s helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He’s also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you’re ready to take your health seriously, this podcast is a great place to start.

👇 Tap Subscribe to learn more about what’s actually happening in your body, and what to do about it.

📘 Read Dr. McCarthy’s Book: Jump Off the Mood Swing – A Sane Woman’s Guide to Her Crazy Hormones https://www.amazon.com/Jump-Off-Mood-Swing-Hormones/dp/0999649604

📲 Follow Dr. McCarthy:

Instagram: @drbrendanmccarthy

TikTok: @drbrendanmccarthy

Website: www.protealife.com

💬 Got a question or topic for a future episode? Let us know in the comments!